Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

Supplement 6

Three documents prepared during 1999 with additions and amendments to Enzyme Nomenclature were approved in May 2000 after public review:

New peptidases (EC 3.4)
Other new enzymes
ATPases and GTPases (all in EC 3.6)
Two more documents with additions and amendments to Enzyme Nomenclature were approved in October 2000 after public review:

New peptidases (EC 3.4)
Other new enzymes
One more document with additions and amendments to Enzyme Nomenclature were approved in December 2000 after public review:

New enzymes
An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.


EC mannitol dehydrogenase
EC fluoren-9-ol dehydrogenase
EC 4-(hydroxymethyl)benzenesulfonate dehydrogenase
EC 6-hydroxyhexanoate dehydrogenase
EC 3-hydroxypimeloyl-CoA dehydrogenase
EC sulcatone reductase
EC glycerol-1-phosphate dehydrogenase [NAD(P)]
EC 4-hydroxythreonine-4-phosphate dehydrogenase
EC 1,5-anhydro-D-fructose reductase
EC L-idonate 5-dehydrogenase
EC 3-methylbutanal reductase
EC 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
EC 4-hydroxymuconic semialdehyde dehydrogenase
EC 4-formylbenzenesulfonate dehydrogenase
EC 6-oxohexanoate dehydrogenase
EC 4-hydroxybenzaldehyde dehydrogenase
EC salicylaldehyde dehydrogenase
EC mycothiol-dependent formaldehyde dehydrogenase
EC vanillin dehydrogenase
EC coniferyl-aldehyde dehydrogenase
EC vanillate demethylase
EC 4-hydroxyphenylpyruvate oxidase
EC cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
EC phloroglucinol reductase
EC 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
EC 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase
EC dibenzothiophene dihydrodiol dehydrogenase
EC terephthalate 1,2-cis-dihydrodiol dehydrogenase
EC pimeloyl-CoA dehydrogenase
EC 2,4-dichlorobenzoyl-CoA reductase
EC phthalate 4,5-cis-dihydrodiol dehydrogenase
EC 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase
EC cis-dihydroethylcatechol dehydrogenase
EC cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
EC 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
EC 4-hydroxybenzoyl-CoA reductase
EC tryptophan α,β-oxidase
EC not approved
EC coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase
EC p-benzoquinone reductase (NADPH)
EC 2-hydroxy-1,4-benzoquinone reductase
*EC NADH2 dehydrogenase
EC phosphoadenylyl-sulfate reductase (thioredoxin)
EC adenylyl-sulfate reductase (glutathione) EC now EC
*EC cytochrome-c oxidase
*EC ubiquinol-cytochrome-c reductase
EC linoleate diol synthase
EC linoleate 11-lipoxygenase
EC apo-β-carotenoid-14',13'-dioxygenase
*EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
EC taurine dioxygenase
EC phytanoyl-CoA dioxygenase
EC nitric oxide dioxygenase
EC quinine 3-monooxygenase
EC 4-hydroxyphenylacetaldehyde oxime monooxygenase
EC choline monooxygenase
EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
EC stearoyl-CoA 9-desaturase
EC acyl-[acyl-carrier-protein] desaturase
EC linoleoyl-CoA desaturase
EC stearoyl-CoA 9-desaturase
EC now EC
EC acyl-[acyl-carrier-protein] 9-desaturase
EC now EC
EC now EC
EC myristoyl-CoA 11-(E) desaturase
EC myristoyl-CoA 11-(Z) desaturase
EC δ12-fatty acid dehydrogenase
EC monoprenyl isoflavone epoxidase
EC thiophene-2-carbonyl-CoA monooxygenase
EC arsenate reductase (glutaredoxin)
EC arsenate reductase (donor)
EC methylarsonate reductase
*EC tetrahydromethanopterin S-methyltransferase
EC chlorophenol O-methyltransferase
EC arsenite methyltransferase
EC methylarsonite methyltransferase
EC 3'-demethylstaurosporine O-methyltransferase
*EC phosphoribosylglycinamide formyltransferase
*EC phosphoribosylaminoimidazolecarboxamide formyltransferase
*EC glycine formimidoyltransferase
*EC glutamate formimidoyltransferase
EC propionyl-CoA C2-trimethyltridecanoyltransferase
EC acetyl-CoA C-myristoyltransferase
EC phloroisovalerophenone synthase
EC cis-p-coumarate glucosyltransferase
EC limonoid glucosyltransferase
*EC glutamine-fructose-6-phosphate transaminase (isomerizing)
EC diaminobutyrate-2-oxoglutarate transaminase
*EC protein-Nπ-phosphohistidine-sugar phosphotransferase
EC feruloyl esterase
EC cutinase
EC 2-(2-hydroxyphenyl)benzenesulfinate hydrolase
*EC 3.1.14 Exoribonucleases Producing 3'-Phosphomonoesters
*EC 3.1.16 Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters
*EC 3.1.31 Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters
*EC oligosaccharide α1,6- glucosidase
*EC amylo-α-1,6-glucosidase
*EC pullulanase
*EC isoamylase
EC limit dextrinase
EC poly(ADP-ribose) glycohydrolase
EC 3-deoxyoctulosonase
*EC DNA-deoxyinosine glycosylase
*EC DNA-3-methyladenine glycosylase I
*EC DNA-3-methyladenine glycosylase II
*EC rRNA N-glycosylase
*EC DNA-formamidopyrimidine glycosylase
EC aspartyl aminopeptidase
EC now EC
*EC cytosol nonspecific dipeptidase
*EC tripeptidyl-peptidase I
*EC carboxypeptidase E
*EC glutamate carboxypeptidase II
EC now EC
*EC cathepsin X
EC ubiquitinyl hydrolase 1
EC assemblin
EC hepacivirin
*EC papain
*EC legumain
EC adenain
EC bleomycin hydrolase
EC cathepsin F
EC cathepsin O
EC cathepsin V
EC nuclear-inclusion-a endopeptidase
*EC HIV-1 retropepsin
EC yapsin 1
EC thermopsin
*EC gametolysin
EC flavastacin
EC 3.4.25 Threonine Endopeptidases
EC proteasome endopeptidase complex
EC now EC
EC now EC
EC biuret amidohydrolase
EC (S)-N-acetyl-1-phenylethylamine hydrolase
EC mandelamide amidase
EC cyanuric acid amidohydrolase
*EC formimidoylaspartate deiminase
*EC formimidoylglutamase
*EC formimidoylglutamate deiminase
*EC IMP cyclohydrolase
*EC phosphoribosyl-AMP cyclohydrolase
EC thiocyanate hydrolase
EC hydroxydechloroatrazine ethylaminohydrolase
EC N-isopropylammelide isopropylaminohydrolase
EC 2-aminomuconate deaminase
EC glucosamine-6-phosphate deaminase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
*EC inorganic diphosphatase
*EC apyrase
EC heterotrimeric G-protein GTPase
EC small monomeric GTPase
EC protein-synthesizing GTPase
EC signal-recognition-particle GTPase
EC dynamin GTPase
EC tubulin GTPase
EC 3.6.3 Acting on acid anhydrides; catalysing transmembrane movement of substances.
EC Mg2+-ATPase
EC Mg2+-importing ATPase
EC Cd2+-exporting ATPase
EC Cu2+-exporting ATPase
EC Zn2+-exporting ATPase
EC H+-exporting ATPase
EC Na+-exporting ATPase
EC Ca2+-transporting ATPase
EC Na+/K+-exchanging ATPase
EC H+/K+-exchanging ATPase
EC Cl--transporting ATPase
EC K+-transporting ATPase
EC aminophospholipid-transporting ATPase
EC H+-transporting two-sector ATPase
EC Na+-transporting two-sector ATPase
EC arsenite-transporting ATPase
EC monosaccharide-transporting ATPase
EC oligosaccharide-transporting ATPase
EC maltose-transporting ATPase
EC glycerol-3-phosphate-transporting ATPase
EC polar-amino-acid-transporting ATPase
EC nonpolar-amino-acid-transporting ATPase
EC oligopeptide-transporting ATPase
EC nickel-transporting ATPase
EC sulfate-transporting ATPase
EC nitrate-transporting ATPase
EC phosphate-transporting ATPase
EC phosphonate-transporting ATPase
EC molybdate-transporting ATPase
EC Fe3+-transporting ATPase
EC polyamine-transporting ATPase
EC quaternary-amine-transporting ATPase
EC vitamin B12-transporting ATPase
EC iron-chelate-transporting ATPase
EC manganese-transporting ATPase
EC taurine-transporting ATPase
EC guanine-transporting ATPase
EC capsular-polysaccharide-transporting ATPase
EC lipopolysaccharide-transporting ATPase
EC teichoic-acid-transporting ATPase
EC heme-transporting ATPase
EC β-glucan-transporting ATPase
EC peptide-transporting ATPase
EC xenobiotic-transporting ATPase
EC steroid-transporting ATPase
EC cadmium-transporting ATPase
EC fatty-acyl-CoA-transporting ATPase
EC α-factor-transporting ATPase
EC channel-conductance-controlling ATPase
EC protein-secreting ATPase
EC mitochondrial protein-transporting ATPase
EC chloroplast protein-transporting ATPase
EC Ag+-exporting ATPase
EC 3.6.4 Acting on acid anhydrides; involved in cellular and subcellular movement.
EC myosin ATPase
EC dynein ATPase
EC microtubule-severing ATPase
EC plus-end-directed kinesin ATPase
EC minus-end-directed kinesin ATPase
EC vesicle-fusing ATPase
EC peroxisome-assembly ATPase
EC proteasome ATPase
EC chaperonin ATPase
EC non-chaperonin molecular chaperone ATPase
EC nucleoplasmin ATPase
EC atrazine chlorohydrolase
*EC oxaloacetate decarboxylase
*EC phosphoribosylaminoimidazole carboxylase
EC acetylenedicarboxylate decarboxylase
EC vanillin synthase
EC now EC
EC now EC
EC pinene synthase
EC now EC
EC myrcene synthase
EC now EC
EC (-)-(4S)-limonene synthase
EC now EC
EC benzylsuccinate synthase
*EC acetylenecarboxylate hydratase
EC now EC
EC cyclohexa-1,5-dienecarbonyl-CoA hydratase
EC trans-feruloyl-CoA hydratase
EC glucuronan lyase
EC 4.2.3 Acting on phosphates
EC threonine synthase
EC ethanolamine-phosphate phospho-lyase
EC methylglyoxal synthase
EC 3-dehydroquinate synthase
EC chorismate synthase
EC trichodiene synthase
EC pentalenene synthase
EC casbene synthase
EC aristolochene synthase
EC (-)-endo-fenchol synthase
EC sabinene-hydrate synthase
EC 6-pyruvoyltetrahydropterin synthase
EC (+)-δ-cadinene synthase
EC pinene synthase
EC myrcene synthase
EC (-)-(4S)-limonene synthase
EC now EC
EC now EC
EC now EC
*EC formimidoyltetrahydrofolate cyclodeaminase
*EC adenylosuccinate lyase
EC deacetylisoipecoside synthase
EC deacetylipecoside synthase
EC prenylcysteine lyase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
*EC 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
EC trans-feruloyl-CoA synthase
*EC phosphoribosylaminoimidazolesuccinocarboxamide synthase
*EC phosphoribosylformylglycinamidine cyclo-ligase
*EC phosphoribosylamine-glycine ligase
*EC phosphoribosylformylglycinamidine synthase

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