Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

Supplement 8

The following documents with additions and amendments to Enzyme Nomenclature have been approved after public review:

New enzymes (January 2002, approved April 2002)
New enzymes (April 2002, approved June 2002)
New enzymes (November 2002, approved January 2003) four files:
   EC 1,   EC 2.1 to EC 2.4,   EC 2.5 to EC 2.8,   EC 3 to EC 6
Minor changes
An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.


*EC hydroxymethylglutaryl-CoA reductase
*EC UDP-N-acetylmuramate dehydrogenase
*EC sterol-4α-carboxylate 3-dehydrogenase (decarboxylating)
*EC dTDP-galactose 6-dehydrogenase
EC 3-keto-steroid reductase
EC GDP-L-fucose synthase
EC (R)-2-hydroxyacid dehydrogenase
EC vellosimine dehydrogenase
EC 2,5-didehydrogluconate reductase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC xylitol oxidase
EC Deleted, see EC cellobiose dehydrogenase (acceptor)
*EC cellobiose dehydrogenase (acceptor)
*EC formaldehyde dehydrogenase (glutathione)
*EC aldehyde oxidase
*EC aryl-aldehyde oxidase
*EC retinal oxidase
*EC δ24(241)-sterol reductase
EC 1,2-dihydrovomilenine reductase
EC secologanin synthase
EC 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
EC phycoerythrobilin:ferredoxin oxidoreductase
EC phytochromobilin:ferredoxin oxidoreductase
EC phycocyanobilin:ferredoxin oxidoreductase
EC now EC
EC glycine oxidase
EC glycine dehydrogenase (cyanide-forming)
EC FMN reductase
*EC FMN reductase
EC flavin reductase
EC berberine reductase
EC vomilenine reductase
EC now EC
EC 1.5.8 With a flavin as acceptor
EC dimethylamine dehydrogenase
EC trimethylamine dehydrogenase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC 1.7.1 With a NAD or NADP as acceptor
EC nitrate reductase (NADH)
EC nitrate reductase [NAD(P)H]
EC nitrate reductase (NADPH)
EC nitrite reductase [NAD(P)H]
EC hyponitrite reductase
EC azobenzene reductase
EC GMP reductase
EC Deleted entry: withdrawn in the light of further information on the acceptor
EC nitroquinoline-N-oxide reductase
EC hydroxylamine reductase (NADH)
EC 4-(dimethylamino)phenylazoxybenzene reductase
EC N-hydroxy-2-acetamidofluorene reductase
*EC nitrite reductase (NO-forming)
EC trimethylamine-N-oxide reductase (cytochrome c)
*EC urate oxidase
*EC hydroxylamine reductase
EC included with EC
EC cystine reductase
EC glutathione-disulfide reductase
EC protein-disulfide reductase
EC thioredoxin-disulfide reductase
EC CoA-glutathione reductase
EC asparagusate reductase
EC trypanothione-disulfide reductase
EC bis-γ-glutamylcystine reductase
EC CoA-disulfide reductase
EC mycothione reductase
EC prenylcysteine oxidase
*EC enzyme-thiol transhydrogenase (glutathione-disulfide)
*EC adenylyl-sulfate reductase (glutathione)
EC included with EC
EC now EC
EC now EC
*EC hydrogen dehydrogenase
EC hydrogen dehydrogenase (NADP)
*EC cytochrome-c3 hydrogenase
EC 1.12.5 With a quinone or similar compound as acceptor
EC hydrogen:quinone oxidoreductase
EC ferredoxin hydrogenase
EC 1.12.98 With other known acceptors
EC coenzyme F420 hydrogenase
EC N5,N10-methenyltetrahydromethanopterin hydrogenase
EC Methanosarcina-phenazine hydrogenase
EC now EC
EC Deleted
EC now EC
EC now EC
EC hydrogenase (acceptor)
*EC inositol oxygenase
*EC pyrimidine-deoxynucleoside 2'-dioxygenase
*EC pyrimidine-deoxynucleoside 1'-dioxygenase
EC desacetoxyvindoline 4-hydroxylase
EC methylsterol monooxygenase
EC tabersonine 16-hydroxylase
EC 7-deoxyloganin 7-hydroxylase
EC vinorine hydroxylase
EC taxane 10β-hydroxylase
EC taxane 13α-hydroxylase
EC ent-kaurene oxidase
EC ent-kaurenoic acid oxidase
EC deleted, identical to EC
EC alkanesulfonate monooxygenase
*EC choline monooxygenase
*EC phenylalanine 4-monooxygenase
EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
EC deacetoxycephalosporin-C synthase
EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated
EC (S)-stylopine synthase
EC (S)-cheilanthifoline synthase
EC berbamunine synthase
EC salutaridine synthase
EC (S)-canadine synthase
EC now EC
EC taxadiene 5α-hydroxylase
EC aquacobalamin reductase
EC cob(II)alamin reductase
EC aquacobalamin reductase (NADPH)
EC cyanocobalamin reductase (cyanide-eliminating)
EC ferric-chelate reductase
EC now EC
EC 1.21.3 With oxygen as acceptor
EC isopenicillin-N synthase
EC columbamine oxidase
EC reticuline oxidase
EC sulochrin oxidase [(+)-bisdechlorogeodin-forming]
EC sulochrin oxidase [(-)-bisdechlorogeodin-forming]
EC 1.21.99 With other acceptors
EC β-cyclopiazonate dehydrogenase
*EC inositol 3-methyltransferase
*EC inositol 1-methyltransferase
*EC inositol 4-methyltransferase
EC now with EC
EC trans-aconitate 2-methyltransferase
EC trans-aconitate 3-methyltransferase
EC (iso)eugenol O-methyltransferase
EC corydaline synthase
*EC methionyl-tRNA formyltransferase
EC 2-hydroxy-3-oxoadipate synthase
EC acetolactate synthase
EC 1-deoxy-D-xylulose-5-phosphate synthase
*EC glucosamine 6-phosphate N-acetyltransferase
*EC tartronate O-hydroxycinnamoyltransferase
EC acridone synthase
EC vinorine synthase
EC lovastatin nonaketide synthase
EC taxadien-5α-ol O-acetyltransferase
EC 10-hydroxytaxane O-acetyltransferase
EC isopenicillin-N N-acyltransferase
EC 6-methylsalicylic acid synthase
EC 2α-hydroxytaxane 2-O-benzoyltransferase
EC 10-deacetylbaccatin III 10-O-acetyltransferase
EC 2.3.3 Acyl groups converted into alkyl on transfer
EC citrate (Si)-synthase
EC decylcitrate synthase
EC citrate (Re)-synthase
EC decylhomocitrate synthase
EC 2-methylcitrate synthase
EC 2-ethylmalate synthase
EC 3-ethylmalate synthase
EC ATP citrate synthase
EC malate synthase
EC hydroxymethylglutaryl-CoA synthase
EC 2-hydroxyglutarate synthase
EC 3-propylmalate synthase
EC 2-isopropylmalate synthase
EC homocitrate synthase
*EC fucosylgalactoside 3-α-galactosyltransferase
*EC lipopolysaccharide 3-α-galactosyltransferase
*EC 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
*EC 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
*EC glycoprotein 6-α-L-fucosyltransferase
*EC galactoside 2-α-L-fucosyltransferase
*EC N-acetyllactosaminide 3-α-galactosyltransferase
EC now included with *EC peptidoglycan glycosyltransferase
*EC xylosylprotein 4-β-galactosyltransferase
*EC galactosylxylosylprotein 3-β-galactosyltransferase
*EC galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase
EC included with EC
*EC 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase
*EC glucuronylgalactosylproteoglycan 4-β-N-acetylgalactosaminyltransferase
*EC glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
*EC phosphatidylinositol N-acetylglucosaminyltransferase
EC glycoprotein 3-α-L-fucosyltransferase
EC mannosyl-3-phosphoglycerate synthase
EC hydroquinone glucosyltransferase
EC vomilenine glucosyltransferase
EC indoxyl-UDPG glucosyltransferase
EC peptide-O-fucosyltransferase
EC O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase
EC glucuronyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase
EC glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-α-N-acetylglucosaminyltransferase
EC N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase
EC N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase
EC undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase
EC lactosylceramide 4-α-galactosyltransferase
*EC protein xylosyltransferase
EC glycoprotein 2-β-D-xylosyltransferase
EC UDP-N-acetylglucosamine 1-carboxyvinyltransferase
*EC adenylate dimethylallyltransferase
EC cysteine synthase
EC cystathionine γ-synthase
EC O-acetylhomoserine aminocarboxypropyltransferase
EC zeatin 9-aminocarboxyethyltransferase
EC β-pyrazolylalanine synthase
EC L-mimosine synthase
EC uracilylalanine synthase
EC 3-deoxy-7-phosphoheptulonate synthase
EC 3-deoxy-8-phosphooctulonate synthase
EC N-acetylneuraminate synthase
EC N-acylneuraminate-9-phosphate synthase
*EC 1-phosphatidylinositol 4-kinase
*EC 1-phosphatidylinositol-4-phosphate 5-kinase
*EC inositol-trisphosphate 3-kinase
EC now included with EC, inositol-tetrakisphosphate 1-kinase
*EC inositol-tetrakisphosphate 1-kinase
*EC phosphatidylinositol 3-kinase
EC now with EC
EC 1-phosphatidylinositol-5-phosphate 4-kinase
EC 1-phosphatidylinositol-3-phosphate 5-kinase
EC inositol-polyphosphate multikinase
EC inositol-hexakisphosphate kinase
EC phosphatidylinositol-4,5-bisphosphate 3-kinase
EC phosphatidylinositol-4-phosphate 3-kinase
*EC pantetheine-phosphate adenylyltransferase
EC holo-ACP synthase
*EC phospho-N-acetylmuramoyl-pentapeptide-transferase
EC triphosphoribosyl-dephospho-CoA synthase
EC α-glucan, water dikinase
*EC glutaconate CoA-transferase
EC protein-glutamate methylesterase
EC now EC
EC polyneuridine-aldehyde esterase
*EC 3-phytase
*EC inositol-1(or 4)-monophosphatase
*EC 4-phytase
*EC phosphoinositide 5-phosphatase
*EC inositol-polyphosphate 5-phosphatase
*EC inositol-1,4-bisphosphate 1-phosphatase
EC deleted
*EC multiple inositol-polyphosphate phosphatase
*EC phosphatidylinositol-3-phosphatase
EC now with EC
*EC phosphatidylinositol-3,4-bisphosphate 4-phosphatase
*EC phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
EC mannosyl-3-phosphoglycerate phosphatase
EC 2-phosphosulfolactate phosphatase
EC 5-phytase
EC now EC
*EC phosphoinositide phospholipase C
EC now with EC
*EC glycerophosphoinositol inositolphosphodiesterase
*EC glycerophosphoinositol glycerophosphodiesterase
EC now EC
*EC glycosylphosphatidylinositol phospholipase D
EC RNase Z
EC deleted, identical to EC
*EC (S)-N-acetyl-1-phenylethylamine hydrolase
EC N-acetylglucosaminylphosphatidylinositol deacetylase
*EC N-acetylglucosaminylphosphatidylinositol deacetylase
EC 1-aminocyclopropane-1-carboxylate deaminase
EC diphosphoinositol-polyphosphate diphosphatase
*EC undecaprenyl-diphosphatase
EC sulfopyruvate decarboxylase
EC 4-hydroxyphenylpyruvate decarboxylase
*EC 2-dehydropantoate aldolase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
*EC tryptophan synthase
EC now EC
*EC pectate lyase
*EC pectate disaccharide-lyase
*EC pectin lyase
*EC 3-dehydroquinate synthase
*EC chorismate synthase
EC taxadiene synthase
EC abietadiene synthase
EC ent-kaurene synthase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
*EC aminodeoxygluconate ammonia-lyase
EC now EC
EC phosphatidylinositol diacylglycerol-lyase
EC glycosylphosphatidylinositol diacylglycerol-lyase
EC FAD-AMP lyase (cyclizing)
EC isopenicillin-N epimerase
EC maltose epimerase
*EC peptidylprolyl isomerase
*EC isopentenyl-diphosphate δ-isomerase
EC squalene—hopene cyclase
EC copalyl diphosphate synthase
EC ent-copalyl diphosphate synthase
*EC tyrosine—tRNA ligase
*EC tryptophan—tRNA ligase
*EC methionine—tRNA ligase
*EC serine—tRNA ligase
EC aspartate—tRNAAsn ligase
EC glutamate—tRNAGln ligase
EC lysine—tRNAPyl ligase
*EC D-alanine—D-alanine ligase
*EC UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
*EC UDP-N-acetylmuramate—L-alanine ligase
*EC UDP-N-acetylmuramoylalanine—D-glutamate ligase
*EC UDP-N-acetylmuramoylalanyl-tripeptide—D-alanyl-D-alanine ligase
*EC UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diamino-pimelate ligase
EC deleted, due to EC
EC N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC aerobactin synthase
EC asparaginyl-tRNA synthase (glutamine-hydrolysing)
EC glutaminyl-tRNA synthase (glutamine-hydrolysing)

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