New enzymes (January 2002, approved April 2002)An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (April 2002, approved June 2002)
New enzymes (November 2002, approved January 2003) four files:
EC 1, EC 2.1 to EC 2.4, EC 2.5 to EC 2.8, EC 3 to EC 6
Minor changes
*EC 1.1.1.88 hydroxymethylglutaryl-CoA reductase
*EC 1.1.1.158 UDP-N-acetylmuramate dehydrogenase
*EC 1.1.1.170 sterol-4α-carboxylate 3-dehydrogenase (decarboxylating)
*EC 1.1.1.186 dTDP-galactose 6-dehydrogenase
EC 1.1.1.270 3-keto-steroid reductase
EC 1.1.1.271 GDP-L-fucose synthase
EC 1.1.1.272 (R)-2-hydroxyacid dehydrogenase
EC 1.1.1.273 vellosimine dehydrogenase
EC 1.1.1.274 2,5-didehydrogluconate reductase
EC 1.1.3.26 now EC 1.21.3.2
EC 1.1.3.32 now EC 1.14.21.1
EC 1.1.3.33 now EC 1.14.21.2
EC 1.1.3.34 now EC 1.14.21.3
EC 1.1.3.35 now EC 1.14.21.4
EC 1.1.3.36 now EC 1.14.21.5
EC 1.1.3.41 xylitol oxidase
EC 1.1.5.1 Deleted, see EC 1.1.99.18 cellobiose dehydrogenase (acceptor)
*EC 1.1.99.18 cellobiose dehydrogenase (acceptor)
*EC 1.2.1.1 formaldehyde dehydrogenase (glutathione)
*EC 1.2.3.1 aldehyde oxidase
*EC 1.2.3.9 aryl-aldehyde oxidase
*EC 1.2.3.11 retinal oxidase
*EC 1.3.1.71 δ24(241)-sterol reductase
EC 1.3.1.73 1,2-dihydrovomilenine reductase
EC 1.3.3.9 secologanin synthase
EC 1.3.7.2 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
EC 1.3.7.3 phycoerythrobilin:ferredoxin oxidoreductase
EC 1.3.7.4 phytochromobilin:ferredoxin oxidoreductase
EC 1.3.7.5 phycocyanobilin:ferredoxin oxidoreductase
EC 1.3.99.9 now EC 1.21.99.1
EC 1.4.3.19 glycine oxidase
EC 1.4.99.5 glycine dehydrogenase (cyanide-forming)
EC 1.5.1.29 FMN reductase
*EC 1.5.1.29 FMN reductase
EC 1.5.1.30 flavin reductase
EC 1.5.1.31 berberine reductase
EC 1.5.1.32 vomilenine reductase
EC 1.5.3.9 now EC 1.21.3.3
EC 1.5.8 With a flavin as acceptor
EC 1.5.8.1 dimethylamine dehydrogenase
EC 1.5.8.2 trimethylamine dehydrogenase
EC 1.5.99.7 now EC 1.5.8.2
EC 1.5.99.10 now EC 1.5.8.1
EC 1.6.4.1 now EC 1.8.1.6
EC 1.6.4.2 now EC 1.8.1.7
EC 1.6.4.4 now EC 1.8.1.8
EC 1.6.4.5 now EC 1.8.1.9
EC 1.6.4.6 now EC 1.8.1.10
EC 1.6.4.7 now EC 1.8.1.11
EC 1.6.4.8 now EC 1.8.1.12
EC 1.6.4.9 now EC 1.8.1.13
EC 1.6.4.10 now EC 1.8.1.14
EC 1.6.6.1 now EC 1.7.1.1
EC 1.6.6.2 now EC 1.7.1.2
EC 1.6.6.3 now EC 1.7.1.3
EC 1.6.6.4 now EC 1.7.1.4
EC 1.6.6.6 now EC 1.7.1.5
EC 1.6.6.7 now EC 1.7.1.6
EC 1.6.6.8 now EC 1.7.1.7
EC 1.6.6.10 now EC 1.7.1.9
EC 1.6.6.11 now EC 1.7.1.10
EC 1.6.6.12 now EC 1.7.1.11
EC 1.6.6.13 now EC 1.7.1.12
EC 1.6.8.1 now EC 1.5.1.29
EC 1.6.8.2 now EC 1.5.1.30
EC 1.6.99.8 now EC 1.16.1.3
EC 1.6.99.9 now EC 1.16.1.4
EC 1.6.99.11 now EC 1.16.1.5
EC 1.6.99.12 now EC 1.16.1.6
EC 1.6.99.13 now EC 1.16.1.7
EC 1.7.1 With a NAD or NADP as acceptor
EC 1.7.1.1 nitrate reductase (NADH)
EC 1.7.1.2 nitrate reductase [NAD(P)H]
EC 1.7.1.3 nitrate reductase (NADPH)
EC 1.7.1.4 nitrite reductase [NAD(P)H]
EC 1.7.1.5 hyponitrite reductase
EC 1.7.1.6 azobenzene reductase
EC 1.7.1.7 GMP reductase
EC 1.7.1.8 Deleted entry: withdrawn in the light of further information on the acceptor
EC 1.7.1.9 nitroquinoline-N-oxide reductase
EC 1.7.1.10 hydroxylamine reductase (NADH)
EC 1.7.1.11 4-(dimethylamino)phenylazoxybenzene reductase
EC 1.7.1.12 N-hydroxy-2-acetamidofluorene reductase
*EC 1.7.2.1 nitrite reductase (NO-forming)
EC 1.7.2.3 trimethylamine-N-oxide reductase (cytochrome c)
*EC 1.7.3.3 urate oxidase
*EC 1.7.99.1 hydroxylamine reductase
EC 1.7.99.3 included with EC 1.7.2.1
EC 1.8.1.6 cystine reductase
EC 1.8.1.7 glutathione-disulfide reductase
EC 1.8.1.8 protein-disulfide reductase
EC 1.8.1.9 thioredoxin-disulfide reductase
EC 1.8.1.10 CoA-glutathione reductase
EC 1.8.1.11 asparagusate reductase
EC 1.8.1.12 trypanothione-disulfide reductase
EC 1.8.1.13 bis-γ-glutamylcystine reductase
EC 1.8.1.14 CoA-disulfide reductase
EC 1.8.1.15 mycothione reductase
EC 1.8.3.5 prenylcysteine oxidase
*EC 1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide)
*EC 1.8.4.9 adenylyl-sulfate reductase (glutathione)
EC 1.9.3.2 included with EC 1.7.2.1
EC 1.10.3.7 now EC 1.21.3.4
EC 1.10.3.8 now EC 1.21.3.5
*EC 1.12.1.2 hydrogen dehydrogenase
EC 1.12.1.3 hydrogen dehydrogenase (NADP)
*EC 1.12.2.1 cytochrome-c3 hydrogenase
EC 1.12.5 With a quinone or similar compound as acceptor
EC 1.12.5.1 hydrogen:quinone oxidoreductase
EC 1.12.7.2 ferredoxin hydrogenase
EC 1.12.98 With other known acceptors
EC 1.12.98.1 coenzyme F420 hydrogenase
EC 1.12.98.2 N5,N10-methenyltetrahydromethanopterin hydrogenase
EC 1.12.98.3 Methanosarcina-phenazine hydrogenase
EC 1.12.99.1 now EC 1.12.98.1
EC 1.12.99.2 Deleted
EC 1.12.99.3 now EC 1.12.5.1
EC 1.12.99.4 now EC 1.12.98.2
EC 1.12.99.6 hydrogenase (acceptor)
*EC 1.13.99.1 inositol oxygenase
*EC 1.14.11.3 pyrimidine-deoxynucleoside 2'-dioxygenase
*EC 1.14.11.10 pyrimidine-deoxynucleoside 1'-dioxygenase
EC 1.14.11.20 desacetoxyvindoline 4-hydroxylase
EC 1.14.13.72 methylsterol monooxygenase
EC 1.14.13.73 tabersonine 16-hydroxylase
EC 1.14.13.74 7-deoxyloganin 7-hydroxylase
EC 1.14.13.75 vinorine hydroxylase
EC 1.14.13.76 taxane 10β-hydroxylase
EC 1.14.13.77 taxane 13α-hydroxylase
EC 1.14.13.78 ent-kaurene oxidase
EC 1.14.13.79 ent-kaurenoic acid oxidase
EC 1.14.14.4 deleted, identical to EC 1.14.15.7
EC 1.14.14.5 alkanesulfonate monooxygenase
*EC 1.14.15.7 choline monooxygenase
*EC 1.14.16.1 phenylalanine 4-monooxygenase
EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
EC 1.14.20.1 deacetoxycephalosporin-C synthase
EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated
EC 1.14.21.1 (S)-stylopine synthase
EC 1.14.21.2 (S)-cheilanthifoline synthase
EC 1.14.21.3 berbamunine synthase
EC 1.14.21.4 salutaridine synthase
EC 1.14.21.5 (S)-canadine synthase
EC 1.14.99.16 now EC 1.14.13.72
EC 1.14.99.37 taxadiene 5α-hydroxylase
EC 1.16.1.3 aquacobalamin reductase
EC 1.16.1.4 cob(II)alamin reductase
EC 1.16.1.5 aquacobalamin reductase (NADPH)
EC 1.16.1.6 cyanocobalamin reductase (cyanide-eliminating)
EC 1.16.1.7 ferric-chelate reductase
EC 1.18.99.1 now EC 1.12.7.2
EC 1.21 ACTING ON X-H AND Y-H TO FORM AN X-Y BOND
EC 1.21.3 With oxygen as acceptor
EC 1.21.3.1 isopenicillin-N synthase
EC 1.21.3.2 columbamine oxidase
EC 1.21.3.3 reticuline oxidase
EC 1.21.3.4 sulochrin oxidase [(+)-bisdechlorogeodin-forming]
EC 1.21.3.5 sulochrin oxidase [(-)-bisdechlorogeodin-forming]
EC 1.21.99 With other acceptors
EC 1.21.99.1 β-cyclopiazonate dehydrogenase
*EC 2.1.1.39 inositol 3-methyltransferase
*EC 2.1.1.40 inositol 1-methyltransferase
*EC 2.1.1.129 inositol 4-methyltransferase
EC 2.1.1.134 now with EC 2.1.1.129
EC 2.1.1.144 trans-aconitate 2-methyltransferase
EC 2.1.1.145 trans-aconitate 3-methyltransferase
EC 2.1.1.146 (iso)eugenol O-methyltransferase
EC 2.1.1.147 corydaline synthase
*EC 2.1.2.9 methionyl-tRNA formyltransferase
EC 2.2.1.5 2-hydroxy-3-oxoadipate synthase
EC 2.2.1.6 acetolactate synthase
EC 2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase
*EC 2.3.1.4 glucosamine 6-phosphate N-acetyltransferase
*EC 2.3.1.106 tartronate O-hydroxycinnamoyltransferase
EC 2.3.1.159 acridone synthase
EC 2.3.1.160 vinorine synthase
EC 2.3.1.161 lovastatin nonaketide synthase
EC 2.3.1.162 taxadien-5α-ol O-acetyltransferase
EC 2.3.1.163 10-hydroxytaxane O-acetyltransferase
EC 2.3.1.164 isopenicillin-N N-acyltransferase
EC 2.3.1.165 6-methylsalicylic acid synthase
EC 2.3.1.166 2α-hydroxytaxane 2-O-benzoyltransferase
EC 2.3.1.167 10-deacetylbaccatin III 10-O-acetyltransferase
EC 2.3.3 Acyl groups converted into alkyl on transfer
EC 2.3.3.1 citrate (Si)-synthase
EC 2.3.3.2 decylcitrate synthase
EC 2.3.3.3 citrate (Re)-synthase
EC 2.3.3.4 decylhomocitrate synthase
EC 2.3.3.5 2-methylcitrate synthase
EC 2.3.3.6 2-ethylmalate synthase
EC 2.3.3.7 3-ethylmalate synthase
EC 2.3.3.8 ATP citrate synthase
EC 2.3.3.9 malate synthase
EC 2.3.3.10 hydroxymethylglutaryl-CoA synthase
EC 2.3.3.11 2-hydroxyglutarate synthase
EC 2.3.3.12 3-propylmalate synthase
EC 2.3.3.13 2-isopropylmalate synthase
EC 2.3.3.14 homocitrate synthase
*EC 2.4.1.37 fucosylgalactoside 3-α-galactosyltransferase
*EC 2.4.1.44 lipopolysaccharide 3-α-galactosyltransferase
*EC 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
*EC 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
*EC 2.4.1.68 glycoprotein 6-α-L-fucosyltransferase
*EC 2.4.1.69 galactoside 2-α-L-fucosyltransferase
*EC 2.4.1.87 N-acetyllactosaminide 3-α-galactosyltransferase
EC 2.4.1.124 now included with
*EC 2.4.1.129 peptidoglycan glycosyltransferase
*EC 2.4.1.133 xylosylprotein 4-β-galactosyltransferase
*EC 2.4.1.134 galactosylxylosylprotein 3-β-galactosyltransferase
*EC 2.4.1.135 galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase
EC 2.4.1.151 included with EC 2.4.1.87
*EC 2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase
*EC 2.4.1.174 glucuronylgalactosylproteoglycan 4-β-N-acetylgalactosaminyltransferase
*EC 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
*EC 2.4.1.198 phosphatidylinositol N-acetylglucosaminyltransferase
EC 2.4.1.214 glycoprotein 3-α-L-fucosyltransferase
EC 2.4.1.217 mannosyl-3-phosphoglycerate synthase
EC 2.4.1.218 hydroquinone glucosyltransferase
EC 2.4.1.219 vomilenine glucosyltransferase
EC 2.4.1.220 indoxyl-UDPG glucosyltransferase
EC 2.4.1.221 peptide-O-fucosyltransferase
EC 2.4.1.222 O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase
EC 2.4.1.223 glucuronyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase
EC 2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-α-N-acetylglucosaminyltransferase
EC 2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase
EC 2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase
EC 2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase
EC 2.4.1.228 lactosylceramide 4-α-galactosyltransferase
*EC 2.4.2.26 protein xylosyltransferase
EC 2.4.2.38 glycoprotein 2-β-D-xylosyltransferase
EC 2.5.1.7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
*EC 2.5.1.27 adenylate dimethylallyltransferase
EC 2.5.1.47 cysteine synthase
EC 2.5.1.48 cystathionine γ-synthase
EC 2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
EC 2.5.1.50 zeatin 9-aminocarboxyethyltransferase
EC 2.5.1.51 β-pyrazolylalanine synthase
EC 2.5.1.52 L-mimosine synthase
EC 2.5.1.53 uracilylalanine synthase
EC 2.5.1.54 3-deoxy-7-phosphoheptulonate synthase
EC 2.5.1.55 3-deoxy-8-phosphooctulonate synthase
EC 2.5.1.56 N-acetylneuraminate synthase
EC 2.5.1.57 N-acylneuraminate-9-phosphate synthase
*EC 2.7.1.67 1-phosphatidylinositol 4-kinase
*EC 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase
*EC 2.7.1.127 inositol-trisphosphate 3-kinase
EC 2.7.1.133 now included with EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase
*EC 2.7.1.134 inositol-tetrakisphosphate 1-kinase
*EC 2.7.1.137 phosphatidylinositol 3-kinase
EC 2.7.1.139 now with EC 2.7.1.134
EC 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase
EC 2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase
EC 2.7.1.151 inositol-polyphosphate multikinase
EC 2.7.1.152 inositol-hexakisphosphate kinase
EC 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
EC 2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase
*EC 2.7.7.3 pantetheine-phosphate adenylyltransferase
EC 2.7.7.61 holo-ACP synthase
*EC 2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferase
EC 2.7.8.25 triphosphoribosyl-dephospho-CoA synthase
EC 2.7.9.4 α-glucan, water dikinase
*EC 2.8.3.12 glutaconate CoA-transferase
EC 3.1.1.61 protein-glutamate methylesterase
EC 3.1.1.69 now EC 3.5.1.89
EC 3.1.1.78 polyneuridine-aldehyde esterase
*EC 3.1.3.8 3-phytase
*EC 3.1.3.25 inositol-1(or 4)-monophosphatase
*EC 3.1.3.26 4-phytase
*EC 3.1.3.36 phosphoinositide 5-phosphatase
*EC 3.1.3.56 inositol-polyphosphate 5-phosphatase
*EC 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
EC 3.1.3.61 deleted
*EC 3.1.3.62 multiple inositol-polyphosphate phosphatase
*EC 3.1.3.64 phosphatidylinositol-3-phosphatase
EC 3.1.3.65 now with EC 3.1.3.64
*EC 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
*EC 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
EC 3.1.3.70 mannosyl-3-phosphoglycerate phosphatase
EC 3.1.3.71 2-phosphosulfolactate phosphatase
EC 3.1.3.72 5-phytase
EC 3.1.4.10 now EC 4.6.1.13
*EC 3.1.4.11 phosphoinositide phospholipase C
EC 3.1.4.36 now with EC 3.1.4.43
*EC 3.1.4.43 glycerophosphoinositol inositolphosphodiesterase
*EC 3.1.4.44 glycerophosphoinositol glycerophosphodiesterase
EC 3.1.4.47 now EC 4.6.1.14
*EC 3.1.4.50 glycosylphosphatidylinositol phospholipase D
EC 3.1.26.11 RNase Z
EC 3.5.1.80 deleted, identical to EC 3.5.1.25
*EC 3.5.1.85 (S)-N-acetyl-1-phenylethylamine hydrolase
EC 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase
*EC 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase
EC 3.5.99.7 1-aminocyclopropane-1-carboxylate deaminase
EC 3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
*EC 3.6.1.27 undecaprenyl-diphosphatase
EC 4.1.1.79 sulfopyruvate decarboxylase
EC 4.1.1.80 4-hydroxyphenylpyruvate decarboxylase
*EC 4.1.2.12 2-dehydropantoate aldolase
EC 4.1.2.15 now EC 2.5.1.54
EC 4.1.2.16 now EC 2.5.1.55
EC 4.1.3.2 now EC 2.3.3.9
EC 4.1.3.5 now EC 2.3.3.10
EC 4.1.3.7 now EC 2.3.3.1
EC 4.1.3.8 now EC 2.3.3.8
EC 4.1.3.9 now EC 2.3.3.11
EC 4.1.3.10 now EC 2.3.3.7
EC 4.1.3.11 now EC 2.3.3.12
EC 4.1.3.12 now EC 2.3.3.13
EC 4.1.3.15 now EC 2.2.1.5
EC 4.1.3.18 now EC 2.2.1.6
EC 4.1.3.19 now EC 2.5.1.56
EC 4.1.3.20 now EC 2.5.1.57
EC 4.1.3.21 now EC 2.3.3.14
EC 4.1.3.23 now EC 2.3.3.2
EC 4.1.3.28 now EC 2.3.3.3
EC 4.1.3.29 now EC 2.3.3.4
EC 4.1.3.31 now EC 2.3.3.5
EC 4.1.3.33 now EC 2.3.3.6
EC 4.1.3.37 now EC 2.2.1.7
EC 4.1.99.4 now EC 3.5.99.7
*EC 4.2.1.20 tryptophan synthase
EC 4.2.1.26 now EC 4.3.1.21
*EC 4.2.2.2 pectate lyase
*EC 4.2.2.9 pectate disaccharide-lyase
*EC 4.2.2.10 pectin lyase
*EC 4.2.3.4 3-dehydroquinate synthase
*EC 4.2.3.5 chorismate synthase
EC 4.2.3.17 taxadiene synthase
EC 4.2.3.18 abietadiene synthase
EC 4.2.3.19 ent-kaurene synthase
EC 4.2.99.8 now EC 2.5.1.47
EC 4.2.99.9 now EC 2.5.1.48
EC 4.2.99.10 now EC 2.5.1.49
EC 4.2.99.13 now EC 2.5.1.50
EC 4.2.99.14 now EC 2.5.1.51
EC 4.2.99.15 now EC 2.5.1.52
EC 4.2.99.16 now EC 2.5.1.53
*EC 4.3.1.21 aminodeoxygluconate ammonia-lyase
EC 4.4.1.18 now EC 1.8.3.5
EC 4.6.1.13 phosphatidylinositol diacylglycerol-lyase
EC 4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase
EC 4.6.1.15 FAD-AMP lyase (cyclizing)
EC 5.1.1.17 isopenicillin-N epimerase
EC 5.1.3.21 maltose epimerase
*EC 5.2.1.8 peptidylprolyl isomerase
*EC 5.3.3.2 isopentenyl-diphosphate δ-isomerase
EC 5.4.99.17 squalene—hopene cyclase
EC 5.5.1.12 copalyl diphosphate synthase
EC 5.5.1.13 ent-copalyl diphosphate synthase
*EC 6.1.1.1 tyrosine—tRNA ligase
*EC 6.1.1.2 tryptophan—tRNA ligase
*EC 6.1.1.10 methionine—tRNA ligase
*EC 6.1.1.11 serine—tRNA ligase
EC 6.1.1.23 aspartate—tRNAAsn ligase
EC 6.1.1.24 glutamate—tRNAGln ligase
EC 6.1.1.25 lysine—tRNAPyl ligase
*EC 6.3.2.4 D-alanine—D-alanine ligase
*EC 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
*EC 6.3.2.8 UDP-N-acetylmuramate—L-alanine ligase
*EC 6.3.2.9 UDP-N-acetylmuramoylalanine—D-glutamate ligase
*EC 6.3.2.10 UDP-N-acetylmuramoylalanyl-tripeptide—D-alanyl-D-alanine ligase
*EC 6.3.2.13 UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diamino-pimelate ligase
EC 6.3.2.15 deleted, due to EC 6.3.2.10
EC 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC 6.3.2.27 aerobactin synthase
EC 6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)
EC 6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)