Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

Supplement 9

The following documents with additions and amendments to Enzyme Nomenclature have been approved after public review:

New enzymes (June 2003, approved August 2003) in two files:
   EC 1    and   EC 2 to EC 6

New peptidase, EC 3.4 (July 2003, approved September 2003)

New enzymes (October 2003, approved December 2003) in two files:
   EC 1    and   EC 2 to EC 6

Minor changes

An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.


EC now EC
*EC GDP-L-fucose synthase
EC (+)-trans-carveol dehydrogenase
EC serine 3-dehydrogenase
EC 3β-hydroxy-5β-steroid dehydrogenase
EC 3β-hydroxy-5α-steroid dehydrogenase
EC (R)-3-hydroxyacid ester dehydrogenase
EC (S)-3-hydroxyacid ester dehydrogenase
EC deleted.
EC quinoprotein glucose dehydrogenase
EC now EC
EC now EC
EC now EC
EC fluoroacetaldehyde dehydrogenase
*EC carbon-monoxide oxygenase (cytochrome b-561)
EC deleted
EC now EC
*EC pyruvate dehydrogenase (acetyl-transferring)
*EC oxoglutarate dehydrogenase (succinyl-transferring)
*EC 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
*EC pyruvate synthase
EC carbon-monoxide dehydrogenase (ferredoxin)
EC aldehyde ferredoxin oxidoreductase
EC glyceraldehyde-3-phosphate ferredoxin reductase
EC 2-oxoisovalerate ferredoxin reductase
EC indolepyruvate ferredoxin oxidoreductase
EC 2-oxoglutarate ferredoxin oxidoreductase
*EC carbon-monoxide dehydrogenase (acceptor)
*EC cyclohexadienyl dehydrogenase
EC 2-alkenal reductase
EC divinyl chlorophyllide a 8-vinyl-reductase
*EC coproporphyrinogen oxidase
*EC protoporphyrinogen oxidase
EC tryptophan α,β-oxidase
EC (R)-benzylsuccinyl-CoA dehydrogenase
*EC serine 2-dehydrogenase
EC now EC
EC now EC
*EC glycine dehydrogenase (decarboxylating)
EC pteridine reductase
EC 6,7-dihydropteridine reductase
*EC NADPH—hemoprotein reductase
EC 1.6.3 With oxygen as acceptor
EC NADPH oxidase
EC now EC
EC hydroxylamine oxidoreductase
*EC dihydrolipoyl dehydrogenase
EC adenylyl-sulfate reductase (thioredoxin)
EC 1.8.98 With other, known, acceptors
EC CoB—CoM heterodisulfide reductase
*EC hydrogenase (acceptor)
EC acetylacetone-cleaving enzyme
*EC phenylalanine 2-monooxygenase
EC clavaminate synthase
EC now EC
*EC (S)-limonene 3-monooxygenase
*EC (S)-limonene 6-monooxygenase
*EC (S)-limonene 7-monooxygenase
EC (R)-limonene 6-monooxygenase
EC magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
EC vanillate monooxygenase
*EC phenylalanine 4-monooxygenase
*EC tyrosine 3-monooxygenase
*EC tryptophan 5-monooxygenase
EC aminocyclopropanecarboxylate oxidase
EC CMP-N-acetylneuraminate monooxygenase
*EC stearoyl-CoA 9-desaturase
EC deleted
EC [methionine synthase] reductase
EC 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC leucoanthocyanidin reductase
EC 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
*EC methylarsonate reductase
EC aureusidin synthase
EC 1.21.4 With a disulfide as acceptor
EC D-proline reductase (dithiol)
EC glycine reductase
EC sarcosine reductase
EC betaine reductase
EC selenate reductase
EC thyroxine 5'-deiodinase
EC thyroxine 5-deiodinase
*EC magnesium protoporphyrin IX methyltransferase
*EC methionine synthase
*EC 5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase
*EC DNA (cytosine-5-)-methyltransferase
*EC methylated-DNA—[protein]-cysteine S-methyltransferase
EC deleted.
EC now EC
*EC arsenite methyltransferase
EC deleted.
EC thymidylate synthase (FAD)
EC myricetin O-methyltransferase
EC isoflavone 7-O-methyltransferase
*EC aminomethyltransferase
EC fluorothreonine transaldolase
*EC dihydrolipoyllysine-residue acetyltransferase
*EC dihydrolipoyllysine-residue succinyltransferase
*EC indoleacetylglucose—inositol O-acyltransferase
*EC fatty-acyl-CoA synthase
EC dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
EC CO-methylating acetyl-CoA synthase
EC sulfoacetaldehyde acetyltransferase
*EC sucrose synthase
*EC phosphatidylinositol α-mannosyltransferase
*EC galactinol—raffinose galactosyltransferase
*EC galactinol—sucrose galactosyltransferase
*EC inositol 3-α-galactosyltransferase
*EC alternansucrase
EC now EC
EC now EC
EC [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
EC kojibiose phosphorylase
EC α,α-trehalose phosphorylase (configuration-retaining)
*EC dolichyl-phosphate D-xylosyltransferase
*EC indolylacetylinositol arabinosyltransferase
EC xyloglucan 6-xylosyltransferase
EC zeatin O-β-D-xylosyltransferase
EC protein farnesyltransferase
EC protein geranylgeranyltransferase type I
EC protein geranylgeranyltransferase type II
EC hydroxymethylbilane synthase
EC chlorophyll synthase
EC adenosyl-fluoride synthase
EC 2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate synthase
*EC taurine—2-oxoglutarate transaminase
EC taurine—pyruvate aminotransferase
EC now EC
EC diphosphoinositol-pentakisphosphate kinase
EC inositol-hexakisphosphate kinase
EC cysteine desulfurase
EC succinyl-CoA:(R)-benzylsuccinate CoA-transferase
EC formyl-CoA transferase
EC cinnamoyl-CoA:phenyllactate CoA-transferase
*EC crossover junction endodeoxyribonuclease
EC now EC
EC oligoxyloglucan reducing-end-specific cellobiohydrolase
EC xyloglucan-specific endo-β-1,4-glucanase
EC PepB aminopeptidase
*EC tripeptidyl-peptidase I
*EC pseudomonalisin
*EC xanthomonalisin
EC physarolisin
EC now EC and EC
EC gingipain K
EC staphopain
EC separase
EC V-cath endopeptidase
EC cruzipain
EC calpain-1
EC calpain-2
EC now EC
EC memapsin 1
EC memapsin 2
EC HIV-2 retropepsin
EC plasminogen activator Pla
EC gpr endopeptidase
EC pappalysin-1
EC membrane-type matrix metalloproteinase-1
EC ADAM10 endopeptidase
EC ADAMTS-4 endopeptidase
EC anthrax lethal factor endopeptidase
EC Ste24 endopeptidase
EC S2P endopeptidase
EC ADAM 17 endopeptidase
EC proclavaminate amidinohydrolase
EC GTP cyclohydrolase IIa
EC dCTP deaminase (dUMP-forming)
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC 3.6.5 Acting on GTP; involved in cellular and subcellular movement
EC heterotrimeric G-protein GTPase
EC small monomeric GTPase
EC protein-synthesizing GTPase
EC signal-recognition-particle GTPase
EC dynamin GTPase
EC tubulin GTPase
*EC (S)-2-haloacid dehalogenase
EC now EC
EC (R)-2-haloacid dehalogenase
EC 2-haloacid dehalogenase (configuration-inverting)
EC 2-haloacid dehalogenase (configuration-retaining)
*EC ribulose-bisphosphate carboxylase
*EC glutaconyl-CoA decarboxylase
EC aminodeoxychorismate lyase
*EC aconitate hydratase
EC anhydrosialidase
*EC (4S)-limonene synthase
EC (R)-limonene synthase
EC now EC
EC deleted.
EC phosphosulfolactate synthase
*EC D-lysine 5,6-aminomutase
*EC D-ornithine 4,5-aminomutase
EC 5.4.4 Transferring hydroxy groups
EC (hydroxyamino)benzene mutase
EC isochorismate synthase
EC 3-(hydroxyamino)phenol mutase
EC now EC
*EC phosphopantothenate—cysteine ligase
EC (carboxyethyl)arginine β-lactam-synthase
EC aminodeoxychorismate synthase
EC 6.6 Forming nitrogen—metal bonds
EC 6.6.1 Forming coordination complexes
EC magnesium chelatase

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