New enzymes (June 2003, approved August 2003) in two files:An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
EC 1 and EC 2 to EC 6New peptidase, EC 3.4 (July 2003, approved September 2003)
New enzymes (October 2003, approved December 2003) in two files:
EC 1 and EC 2 to EC 6
EC 1.1.1.253 now EC 1.5.1.33
*EC 1.1.1.271 GDP-L-fucose synthase
EC 1.1.1.275 (+)-trans-carveol dehydrogenase
EC 1.1.1.276 serine 3-dehydrogenase
EC 1.1.1.277 3β-hydroxy-5β-steroid dehydrogenase
EC 1.1.1.278 3β-hydroxy-5α-steroid dehydrogenase
EC 1.1.1.279 (R)-3-hydroxyacid ester dehydrogenase
EC 1.1.1.280 (S)-3-hydroxyacid ester dehydrogenase
EC 1.1.3.31 deleted.
EC 1.1.5.2 quinoprotein glucose dehydrogenase
EC 1.1.99.17 now EC 1.1.5.2
EC 1.2.1.55 now EC 1.1.1.279
EC 1.2.1.56 now EC 1.1.1.280
EC 1.2.1.69 fluoroacetaldehyde dehydrogenase
*EC 1.2.2.4 carbon-monoxide oxygenase (cytochrome b-561)
EC 1.2.3.10 deleted
EC 1.2.3.12 now EC 1.14.13.82
*EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
*EC 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
*EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
*EC 1.2.7.1 pyruvate synthase
EC 1.2.7.4 carbon-monoxide dehydrogenase (ferredoxin)
EC 1.2.7.5 aldehyde ferredoxin oxidoreductase
EC 1.2.7.6 glyceraldehyde-3-phosphate ferredoxin reductase
EC 1.2.7.7 2-oxoisovalerate ferredoxin reductase
EC 1.2.7.8 indolepyruvate ferredoxin oxidoreductase
EC 1.2.7.9 2-oxoglutarate ferredoxin oxidoreductase
*EC 1.2.99.2 carbon-monoxide dehydrogenase (acceptor)
*EC 1.3.1.43 cyclohexadienyl dehydrogenase
EC 1.3.1.74 2-alkenal reductase
EC 1.3.1.75 divinyl chlorophyllide a 8-vinyl-reductase
*EC 1.3.3.3 coproporphyrinogen oxidase
*EC 1.3.3.4 protoporphyrinogen oxidase
EC 1.3.3.10 tryptophan α,β-oxidase
EC 1.3.99.21 (R)-benzylsuccinyl-CoA dehydrogenase
*EC 1.4.1.7 serine 2-dehydrogenase
EC 1.4.3.17 now EC 1.3.3.10
EC 1.4.4.1 now EC 1.21.4.1
*EC 1.4.4.2 glycine dehydrogenase (decarboxylating)
EC 1.5.1.33 pteridine reductase
EC 1.5.1.34 6,7-dihydropteridine reductase
*EC 1.6.2.4 NADPH—hemoprotein reductase
EC 1.6.3 With oxygen as acceptor
EC 1.6.3.1 NADPH oxidase
EC 1.6.99.7 now EC 1.5.1.34
EC 1.7.99.8 hydroxylamine oxidoreductase
*EC 1.8.1.4 dihydrolipoyl dehydrogenase
EC 1.8.4.10 adenylyl-sulfate reductase (thioredoxin)
EC 1.8.98 With other, known, acceptors
EC 1.8.98.1 CoB—CoM heterodisulfide reductase
*EC 1.12.99.6 hydrogenase (acceptor)
EC 1.13.11.50 acetylacetone-cleaving enzyme
*EC 1.13.12.9 phenylalanine 2-monooxygenase
EC 1.14.11.21 clavaminate synthase
EC 1.14.13.45 now EC 1.14.18.2
*EC 1.14.13.47 (S)-limonene 3-monooxygenase
*EC 1.14.13.48 (S)-limonene 6-monooxygenase
*EC 1.14.13.49 (S)-limonene 7-monooxygenase
EC 1.14.13.80 (R)-limonene 6-monooxygenase
EC 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
EC 1.14.13.82 vanillate monooxygenase
*EC 1.14.16.1 phenylalanine 4-monooxygenase
*EC 1.14.16.2 tyrosine 3-monooxygenase
*EC 1.14.16.4 tryptophan 5-monooxygenase
EC 1.14.17.4 aminocyclopropanecarboxylate oxidase
EC 1.14.18.2 CMP-N-acetylneuraminate monooxygenase
*EC 1.14.19.1 stearoyl-CoA 9-desaturase
EC 1.14.99.18 deleted
EC 1.16.1.8 [methionine synthase] reductase
EC 1.17.1.2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC 1.17.1.3 leucoanthocyanidin reductase
EC 1.17.4.3 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
*EC 1.20.4.2 methylarsonate reductase
EC 1.21.3.6 aureusidin synthase
EC 1.21.4 With a disulfide as acceptor
EC 1.21.4.1 D-proline reductase (dithiol)
EC 1.21.4.2 glycine reductase
EC 1.21.4.3 sarcosine reductase
EC 1.21.4.4 betaine reductase
EC 1.97.1.9 selenate reductase
EC 1.97.1.10 thyroxine 5'-deiodinase
EC 1.97.1.11 thyroxine 5-deiodinase
*EC 2.1.1.11 magnesium protoporphyrin IX methyltransferase
*EC 2.1.1.13 methionine synthase
*EC 2.1.1.14 5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase
*EC 2.1.1.37 DNA (cytosine-5-)-methyltransferase
*EC 2.1.1.63 methylated-DNA—[protein]-cysteine S-methyltransferase
EC 2.1.1.73 deleted.
EC 2.1.1.135 now EC 1.16.1.8
*EC 2.1.1.137 arsenite methyltransferase
EC 2.1.1.138 deleted.
EC 2.1.1.148 thymidylate synthase (FAD)
EC 2.1.1.149 myricetin O-methyltransferase
EC 2.1.1.150 isoflavone 7-O-methyltransferase
*EC 2.1.2.10 aminomethyltransferase
EC 2.2.1.8 fluorothreonine transaldolase
*EC 2.3.1.12 dihydrolipoyllysine-residue acetyltransferase
*EC 2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
*EC 2.3.1.72 indoleacetylglucose—inositol O-acyltransferase
*EC 2.3.1.86 fatty-acyl-CoA synthase
EC 2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
EC 2.3.1.169 CO-methylating acetyl-CoA synthase
EC 2.3.3.15 sulfoacetaldehyde acetyltransferase
*EC 2.4.1.13 sucrose synthase
*EC 2.4.1.57 phosphatidylinositol α-mannosyltransferase
*EC 2.4.1.67 galactinol—raffinose galactosyltransferase
*EC 2.4.1.82 galactinol—sucrose galactosyltransferase
*EC 2.4.1.123 inositol 3-α-galactosyltransferase
*EC 2.4.1.140 alternansucrase
EC 2.4.1.169 now EC 2.4.2.39
EC 2.4.1.204 now EC 2.4.2.40
EC 2.4.1.229 [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
EC 2.4.1.230 kojibiose phosphorylase
EC 2.4.1.231 α,α-trehalose phosphorylase (configuration-retaining)
*EC 2.4.2.32 dolichyl-phosphate D-xylosyltransferase
*EC 2.4.2.34 indolylacetylinositol arabinosyltransferase
EC 2.4.2.39 xyloglucan 6-xylosyltransferase
EC 2.4.2.40 zeatin O-β-D-xylosyltransferase
EC 2.5.1.58 protein farnesyltransferase
EC 2.5.1.59 protein geranylgeranyltransferase type I
EC 2.5.1.60 protein geranylgeranyltransferase type II
EC 2.5.1.61 hydroxymethylbilane synthase
EC 2.5.1.62 chlorophyll synthase
EC 2.5.1.63 adenosyl-fluoride synthase
EC 2.5.1.64 2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate synthase
*EC 2.6.1.55 taurine—2-oxoglutarate transaminase
EC 2.6.1.77 taurine—pyruvate aminotransferase
EC 2.7.1.152 now EC 2.7.4.21
EC 2.7.1.155 diphosphoinositol-pentakisphosphate kinase
EC 2.7.4.21 inositol-hexakisphosphate kinase
EC 2.8.1.7 cysteine desulfurase
EC 2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase
EC 2.8.3.16 formyl-CoA transferase
EC 2.8.3.17 cinnamoyl-CoA:phenyllactate CoA-transferase
*EC 3.1.22.4 crossover junction endodeoxyribonuclease
EC 3.2.1.138 now EC 4.2.2.15
EC 3.2.1.150 oligoxyloglucan reducing-end-specific cellobiohydrolase
EC 3.2.1.151 xyloglucan-specific endo-β-1,4-glucanase
EC 3.4.11.23 PepB aminopeptidase
*EC 3.4.14.9 tripeptidyl-peptidase I
*EC 3.4.21.100 pseudomonalisin
*EC 3.4.21.101 xanthomonalisin
EC 3.4.21.103 physarolisin
EC 3.4.22.17 now EC 3.4.22.52 and EC 3.4.22.53
EC 3.4.22.47 gingipain K
EC 3.4.22.48 staphopain
EC 3.4.22.49 separase
EC 3.4.22.50 V-cath endopeptidase
EC 3.4.22.51 cruzipain
EC 3.4.22.52 calpain-1
EC 3.4.22.53 calpain-2
EC 3.4.23.27 now EC 3.4.21.103
EC 3.4.23.45 memapsin 1
EC 3.4.23.46 memapsin 2
EC 3.4.23.47 HIV-2 retropepsin
EC 3.4.23.48 plasminogen activator Pla
EC 3.4.24.78 gpr endopeptidase
EC 3.4.24.79 pappalysin-1
EC 3.4.24.80 membrane-type matrix metalloproteinase-1
EC 3.4.24.81 ADAM10 endopeptidase
EC 3.4.24.82 ADAMTS-4 endopeptidase
EC 3.4.24.83 anthrax lethal factor endopeptidase
EC 3.4.24.84 Ste24 endopeptidase
EC 3.4.24.85 S2P endopeptidase
EC 3.4.24.86 ADAM 17 endopeptidase
EC 3.5.3.22 proclavaminate amidinohydrolase
EC 3.5.4.29 GTP cyclohydrolase IIa
EC 3.5.4.30 dCTP deaminase (dUMP-forming)
EC 3.6.1.46 now EC 3.6.5.1
EC 3.6.1.47 now EC 3.6.5.2
EC 3.6.1.48 now EC 3.6.5.3
EC 3.6.1.49 now EC 3.6.5.4
EC 3.6.1.50 now EC 3.6.5.5
EC 3.6.1.51 now EC 3.6.5.6
EC 3.6.5 Acting on GTP; involved in cellular and subcellular movement
EC 3.6.5.1 heterotrimeric G-protein GTPase
EC 3.6.5.2 small monomeric GTPase
EC 3.6.5.3 protein-synthesizing GTPase
EC 3.6.5.4 signal-recognition-particle GTPase
EC 3.6.5.5 dynamin GTPase
EC 3.6.5.6 tubulin GTPase
*EC 3.8.1.2 (S)-2-haloacid dehalogenase
EC 3.8.1.4 now EC 1.97.1.10
EC 3.8.1.9 (R)-2-haloacid dehalogenase
EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)
*EC 4.1.1.39 ribulose-bisphosphate carboxylase
*EC 4.1.1.70 glutaconyl-CoA decarboxylase
EC 4.1.3.38 aminodeoxychorismate lyase
*EC 4.2.1.3 aconitate hydratase
EC 4.2.2.15 anhydrosialidase
*EC 4.2.3.16 (4S)-limonene synthase
EC 4.2.3.20 (R)-limonene synthase
EC 4.3.1.8 now EC 2.5.1.61
EC 4.4.1.12 deleted.
EC 4.4.1.19 phosphosulfolactate synthase
*EC 5.4.3.4 D-lysine 5,6-aminomutase
*EC 5.4.3.5 D-ornithine 4,5-aminomutase
EC 5.4.4 Transferring hydroxy groups
EC 5.4.4.1 (hydroxyamino)benzene mutase
EC 5.4.4.2 isochorismate synthase
EC 5.4.4.3 3-(hydroxyamino)phenol mutase
EC 5.4.99.6 now EC 5.4.4.2
*EC 6.3.2.5 phosphopantothenate—cysteine ligase
EC 6.3.3.4 (carboxyethyl)arginine β-lactam-synthase
EC 6.3.5.8 aminodeoxychorismate synthase
EC 6.6 Forming nitrogen—metal bonds
EC 6.6.1 Forming coordination complexes
EC 6.6.1.1 magnesium chelatase