Classification of Membrane Transport Proteins

2003 Changes

List of Families and Subfamilies of the TC System

  1.A.30.1 H+- or Na+-translocating bacterial flagellar motor Mot
  1.A.30.2 TonB-ExbB-ExbD/TolA-TolQ-TolR of energizers for outer-membrane receptor (OMR)-mediated active transport Exb
1.C.53 Bacteriocin AS-48 cyclic polypeptide Bacteriocin AS-48
1.A.30H+- or Na+-translocating MotAB flagellar motor
1.A.37CD20 Ca2+ channelCD20
1.A.38Poliovirus 2B viroporin2B Viroporin
1.A.39Type C influenza virus CM2 channelCM2-C
1.A.40Human immunodeficiency virus type 1 channelVpu-C
1.B.35Oligogalacturonate-specific poriKdgM
1.B.36Borrelia porin p13BP-p13
1.B.37Leptospira porin OmpL1LP-OmpL1
1.B.38Treponema porin major surface proteinTP-MSP
1.C.59Clostridium perfringens enterotoxinCPE
1.C.60Two-component Enterococcus faecalis cytolysinEFC
1.C.61Streptococcus pyogenes streptolysin SStreptolysin S
1.C.62Pseudopleuronectes americanus pleurocidin Pleurocidin
1.C.64Fst toxinFst
1.C.65Plant host cell membrane pore-forming protein of type III protein secretion systemHrpF
1.E.20Pseudomonas aeruginosa Hol holinHol Holin
1.E.21Listeria phage A118 holinholin118
2.A.81Aspartate:alanine exchangerAAE
2.CIon-gradient-driven energizers
2.C.1TonB-ExbB-ExbD/TolA-TolQ-TolR proteins for energization of outer-membrane-receptor-mediated transportTonB
3.A.1.122Macrolide exporterMacB
3.A.1.123Peptide-4 exporterPep4E
3.A.1.124Three-component peptide-5 exporterPep5E
3.A.1.125Lipoprotein translocaseLPT
3.A.1.126b-Exotoxin I exporterb ETE
3.A.15Outer membrane protein secreting main terminal branchMTB
4.A.7l-Ascorbate PTSl-Asc
5.A.3Prokaryotic molybdopterin-containing oxidoreductasePMO

Changes in the Properties of Families Section

 1.A.30.1MotH+; Na+ 200-350 (MotA)200-500 (MotB)41B2MotA and MotB proteins of Escherichia coli
 1.A.30.2 ExbH+ (energy-transducing system)150-400+150- 350+100-200 (TonB ExbBD) 350-450+200- 300+100-200 (TolAQR)1+3+1


B(G-)2TonB/ExbB/ExbD of Escherichia coli
1.C.53Bacteriocin AS-48ions and small molecules 70 (cyclic) (precursors: 105)1B(G+)0bacteriocin AS-48 of Enterococcus faecalis
1.D.11PEAmainly K+, also organic compoundsno amino acids, c. 920 Da-B1amphotericin B of Streptomyces nodosus
1.A.30MotH+; Na+ 200-350 (MotA)200-500 (MotB)41B2MotA and MotB proteins of Escherichia coli
1.A.37CD20Ca2+2974E(An) 0CD20 of Homo sapiens
1.A.382B Viroporinmolecules smaller than 1 kDa97nonstructural tetramerV02B viroporin of poliovirus
1.A.39CM2-Csmall molecules1392V0CM2 of type C influenza virus
1.A.40Vpu-Cions (mainly univalent cations)81homopentamerE(An)0Vpu of HIV-1
1.B.35KdgManions preferred236monomericB(G-)0KdgM of Erwinia chrysanthemi
1.B.36BP-p13cationsc. 115partly a-helicalB0p13 porin of Borrelia burgdorferi
1.B.37LP-OmpL1small moleculesc. 270trimericB0OmpL1 of Leptospira kirschneri
1.B.38TP-MSPions474hexagonalB0Msp of Treponema denticola
1.C.59CPEsmall molecules309forms complexesB1enterotoxin of Clostridium perfringens
1.C.60EFSsmall molecules68+63forms complexesB(G+)0CylL of Enterococcus faecalis
1.C.61Streptolysin Ssmall molecules531B0SagA of Streptococcus pyogenes
1.C.62Pleurocidinsmall molecules25toroidal poreE(fish)0pleurocidin of Pseudopleuronectes americanus
1.C.63Latrotoxincations4 ? c. 1050tetrameric poreE(spiders)0a-latrotoxin of Latrodectus mactans
1.C.64Fstsmall molecules (selective)33?B0Fst of Enterococcus faecalis plasmid pAD1
1.C.65HrpFproteins8063(?) part of transloconB0HrpF of Xanthomonas campestris
1.D.12Beauvericincations (mainly Na+, K+, Ca2+)cyclic hexadepsipeptide of d-a-hydroxyisovaleryl and N-methylphenylalanyl residuesB0beauvericin of Beauveria bassiana
1.E.20HolHolin autolysin1171-2B(G-)1Hol of Pseudomonas aeruginosa PAO1
1.E.21hol118small molecules, autolysin933Bp0hol118 of Listeria monocytogenes phage A118
2.A.81AAEaspartate:alanine54311-13B(G-)1AspT of Tetragenococcus halophila
2.C.Ion-gradient-driven transporters
These proteins use proton-motive or sodium-motive force to energize the movement of substances through porins or other bacterial outer membrane receptors against concentration gradients.
2.C.1TonBvarious molecules (colicin, vitamin B12, siderophores and others)239+244+141/ mainly 412+230+1423B(G-)1TonB/ExbBD system of Escherichia coli
3.A.15MTBfolded proteins>14 proteins variousB1pullulanase secretion system of Klebsiella pneumoniae
4.A.7L-Ascl-ascorbate3proteins (SgaTBA with 12 TMS)B1l-ascorbate IIC-IIB-IIA complex of Escherichia coli
5.A.3PMO2 e-2_1247 2_512 4_2255 (plus nonintegral proteins)B, A1NarGHI of Escherichia coli

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