IUBMB Enzyme Nomenclature


Accepted name: 20α-hydroxysteroid dehydrogenase

Reaction: 17α,20α-dihydroxypregn-4-en-3-one + NAD(P)+ = 17α-hydroxyprogesterone + NAD(P)H + H+

Other name(s): 20α-hydroxy steroid dehydrogenase; 20α-hydroxy steroid dehydrogenase; 20α-HSD; 20α-HSDH

Systematic name: 20α-hydroxysteroid:NAD(P)+ 20-oxidoreductase

Comments: Re-specific with respect to NAD(P)+ (cf. EC 17β-estradiol 17-dehydrogenase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9040-08-8


1. Shikita, M., Inano, H. and Tamaoki, B. Further studies on 20α-hydroxysteroid dehydrogenase of rat testes. Biochemistry 6 (1967) 1760-1764. [PMID: 4382486]

2. Strickler, R.C., Tobias, B. and Covey, D.F. Human placental 17β-estradiol dehydrogenase and 20α-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site. J. Biol. Chem. 256 (1981) 316-321. [PMID: 6935192]

[EC created 1972, deleted 1983, reinstated 1986]

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