IUBMB Enzyme Nomenclature


Accepted name: shikimate dehydrogenase (NADP+)

Reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+

For diagram of reaction, click here

Other name(s): shikimate dehydrogenase; dehydroshikimic reductase; shikimate oxidoreductase; shikimate:NADP+ oxidoreductase; 5-dehydroshikimate reductase; shikimate 5-dehydrogenase; 5-dehydroshikimic reductase; DHS reductase; shikimate:NADP+ 5-oxidoreductase; AroE

Systematic name: shikimate:NADP+ 3-oxidoreductase

Comments: NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC, 3-dehydroquinate dehydratase [4]. cf. EC, quinate/shikimate dehydrogenase (NAD+), EC, quinate/shikimate dehydrogenase (quinone), and EC, quinate/shikimate dehydrogenase [NAD(P)+].

Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9026-87-3


1. Mitsuhashi, S. and Davis, B.D. Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase. Biochim. Biophys. Acta 15 (1954) 268-280. [PMID: 13208693]

2. Yaniv, H. and Gilvarg, C. Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase. J. Biol. Chem. 213 (1955) 787-795. [PMID: 14367339]

3. Balinsky, D. and Davies, D.D. Aromatic biosynthesis in higher plants. 1. Preparation and properties of dehydroshikimic reductase. Biochem. J. 80 (1961) 292-296. [PMID: 13686342]

4. Chaudhuri, S. and Coggins, J.R. The purification of shikimate dehydrogenase from Escherichia coli. Biochem. J. 226 (1985) 217-223. [PMID: 3883995]

5. Anton, I.A. and Coggins, J.R. Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase. Biochem. J. 249 (1988) 319-326. [PMID: 3277621]

6. Ye, S., Von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V. and McRee, D.E. The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode. J. Bacteriol. 185 (2003) 4144-4151. [PMID: 12837789]

[EC created 1961, modified 1976, modified 2004, modified 2021]

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