IUBMB Enzyme Nomenclature


Accepted name: diacetyl reductase [(R)-acetoin forming]

Reaction: (R)-acetoin + NAD+ = diacetyl + NADH + H+

Other name(s): (R)-acetoin dehydrogenase

Systematic name: (R)-acetoin:NAD+ oxidoreductase

Comments: The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC or EC While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae [1,2]. Different from EC, diacetyl reductase [(S)-acetoin forming].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Heidlas, J. and Tressl, R. Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae. Arch. Microbiol. 154 (1990) 267-273. [PMID: 2222122]

2. Gonzalez, E., Fernandez, M.R., Larroy, C., Sola, L., Pericas, M.A., Pares, X. and Biosca, J.A. Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene. J. Biol. Chem. 275 (2000) 35876-35885. [PMID: 10938079]

[EC created 2010 (EC created 1961 part created 2010)]

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