IUBMB Enzyme Nomenclature


Accepted name: phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)

Reaction: 6-phospho-D-gluconate + NAD+ = D-ribulose 5-phosphate + CO2 + NADH + H+

For diagram of reaction click here.

Other name(s): 6-PGDH (ambiguous); gntZ (gene name); GNDl

Systematic name: 6-phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating)

Comments: Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway [4]. cf. EC, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number:


1. Kiriuchin, M. Y., Kletsova, L. V., Chistoserdov, A. Y. and Tsygankov, Y. D. Properties of glucose 6-phosphate and 6-phosphogluconate dehydrogenases of the obligate methylotroph Methylobacillus flagellatum KT. FEMS Microbiology Letters 52 (1988) 199-204.

2. Ohara, H., Russell, R.A., Uchida, K. and Kondo, H. Purification and characterization of NAD-specific 6-phosphogluconate dehydrogenase from Leuconostoc lactis SHO-54. J. Biosci. Bioeng. 98 (2004) 126-128. [PMID: 16233677]

3. Zamboni, N., Fischer, E., Laudert, D., Aymerich, S., Hohmann, H.P. and Sauer, U. The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway. J. Bacteriol. 186 (2004) 4528-4534. [PMID: 15231785]

4. Chistoserdova, L., Gomelsky, L., Vorholt, J.A., Gomelsky, M., Tsygankov, Y.D. and Lidstrom, M.E. Analysis of two formaldehyde oxidation pathways in Methylobacillus flagellatus KT, a ribulose monophosphate cycle methylotroph. Microbiology 146 (2000) 233-238. [PMID: 10658669]

[EC created 2013]

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