Pentose Phosphate Pathway (early stages)

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This reaction generates NADPH, which is used in many syntheses, e.g. of fatty acids. Its overall reaction is:

glucose 6-phosphate + 2 NADP⁺ + H₂O = pentose 5-phosphate + 2 NADPH + CO₂ + 2 H⁺

The above steps also make ribose 5-phosphate for nucleotide biosynthesis.

For the net reaction of both early and late stages of the pentose phosphate pathway click here.

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pentose phosphate pathway (later stages)
pentose phosphate pathway (overall reaction)
riboflavin biosynthesis
ribose activation
EC 1.1.1.44 phosphogluconate dehydrogenase (NADP⁺-dependent, decarboxylating)
EC 1.1.1.49 glucose-6-phosphate dehydrogenase
EC 1.1.1.343 phosphogluconate dehydrogenase (NAD⁺-dependent, decarboxylating)
EC 1.1.1.351 phosphogluconate dehydrogenase (NAD(P)⁺-dependent, decarboxylating)
EC 3.1.1.31 6-phosphogluconolactonase
EC 5.1.3.1 ribulose-phosphate 3-epimerase
EC 5.3.1.6 ribose-5-phosphate isomerase