IUBMB Enzyme Nomenclature


Accepted name: 2-dehydropantolactone reductase

Reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+

Other name(s): 2-oxopantoyl lactone reductase; 2-ketopantoyl lactone reductase; ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase

Systematic name: (R)-pantolactone:NADP+ oxidoreductase

Comments: The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 2-dehydropantolactone reductase (Re-specific) and EC, 2-dehydropantolactone reductase (Si-specific).

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, PDB, CAS registry number:


1. Hata, H., Shimizu, S., Hattori, S. and Yamada, H. Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase. Biochim. Biophys. Acta 990 (1989) 175-181. [PMID: 2644973]

[EC created 2013]

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