IUBMB Enzyme Nomenclature


Accepted name: scyllo-inositol 2-dehydrogenase (NAD+)

Reaction: scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

For diagram of reaction click here.

Glossary: 2,4,6/3,5-pentahydroxycyclohexanone = (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone = scyllo-inosose

Other name(s): iolX (gene name)

Systematic name: scyllo-inositol:NAD+ 2-oxidoreductase

Comments: The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Morinaga, T., Ashida, H. and Yoshida, K. Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis. Microbiology 156 (2010) 1538-1546. [PMID: 20133360]

[EC created 2014]

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