IUBMB Enzyme Nomenclature


Accepted name: L-rhamnose 1-dehydrogenase [NAD(P)+]

Reaction: L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+

Systematic name: L-rhamnose:NAD(P)+ 1-oxidoreductase

Comments: The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC, L-rhamnose 1-dehydrogenase (NADP+).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Watanabe, S., Saimura, M. and Makino, K. Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism. J. Biol. Chem. 283 (2008) 20372-20382. [PMID: 18505728]

2. Watanabe, S. and Makino, K. Novel modified version of nonphosphorylated sugar metabolism - an alternative L-rhamnose pathway of Sphingomonas sp. FEBS J. 276 (2009) 1554-1567. [PMID: 19187228]

[EC created 2014]

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