IUBMB Enzyme Nomenclature


Accepted name: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)

Reaction: D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+

Other name(s): xacA (gene name); xdh (gene name)

Systematic name: D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)

Comments: The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Johnsen, U. and Schonheit, P. Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui. J. Bacteriol. 186 (2004) 6198-6207. [PMID: 15342590]

2. Johnsen, U., Dambeck, M., Zaiss, H., Fuhrer, T., Soppa, J., Sauer, U. and Schonheit, P. D-Xylose degradation pathway in the halophilic archaeon Haloferax volcanii. J. Biol. Chem. 284 (2009) 27290-27303. [PMID: 19584053]

3. Sutter, J.M., Johnsen, U. and Schonheit, P. Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii. FEMS Microbiol. Lett. 364 (2017) . [PMID: 28854683]

[EC created 2020]

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