IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxy-3-prenylphenylpyruvate oxygenase

Reaction: 3(4-hydroxy-3-prenylphenyl)pyruvate + O2 = 4-hydroxy-3-prenylmandelate + CO2

For diagram of reaction, click here

Glossary: 3-(4-hydroxy-3-prenylphenyl)pyruvate = 3-(4-hydroxy-3-prenylphenyl)-2-oxopropanoate
4-hydroxy-3-prenylmandelate = 2-hydroxy-2-(4-hydroxy-3-prenylphenyl)acetate
prenyl = 3-methylbut-2-en-1-yl

Other name(s): CloR

Systematic name: 4-hydroxy-3-prenylphenylpyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate forming)

Comments: Requires non-heme-Fe(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC, 4-hydroxy-3-prenylbenzoate synthase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Pojer, F., Kahlich, R., Kammerer, B., Li, S.M. and Heide, L. CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J. Biol. Chem. 278 (2003) 30661-30668. [PMID: 12777382]

[EC created 2017]

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