Reaction: 3(4-hydroxy-3-prenylphenyl)pyruvate + O2 = 4-hydroxy-3-prenylmandelate + CO2
For diagram of reaction, click here
Glossary: 3-(4-hydroxy-3-prenylphenyl)pyruvate = 3-(4-hydroxy-3-prenylphenyl)-2-oxopropanoate
4-hydroxy-3-prenylmandelate = 2-hydroxy-2-(4-hydroxy-3-prenylphenyl)acetate
prenyl = 3-methylbut-2-en-1-yl
Other name(s): CloR
Systematic name: 4-hydroxy-3-prenylphenylpyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate forming)
Comments: Requires non-heme-Fe(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Pojer, F., Kahlich, R., Kammerer, B., Li, S.M. and Heide, L. CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J. Biol. Chem. 278 (2003) 30661-30668. [PMID: 12777382]