IUBMB Enzyme Nomenclature


Accepted name: L-proline cis-4-hydroxylase

Reaction: L-proline + 2-oxoglutarate + O2 = cis-4-hydroxy-L-proline + succinate + CO2

Systematic name: L-proline,2-oxoglutarate:oxygen oxidoreductase (cis-4-hydroxylating)

Comments: Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC, L-proline trans-4-hydroxylase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Hara, R. and Kino, K. Characterization of novel 2-oxoglutarate dependent dioxygenases converting L-proline to cis-4-hydroxy-L-proline. Biochem. Biophys. Res. Commun. 379 (2009) 882-886. [PMID: 19133227]

[EC created 2017]

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