IUBMB Enzyme Nomenclature


Accepted name: salicylate 5-hydroxylase

Reaction: salicylate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O

Glossary: 2,5-dihydroxybenzoate = gentisate

Other name(s): nagG (gene name); nagH (gene name)

Systematic name: salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)

Comments: This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC, ferredoxin—NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Fuenmayor, S.L., Wild, M., Boyes, A.L. and Williams, P.A. A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2. J. Bacteriol. 180 (1998) 2522-2530. [PMID: 9573207]

[EC created 2013]

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