Reaction: 2 reduced [2Fe-2S] ferredoxin + NAD(P)+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NAD(P)H
Other name(s): NADH-ferredoxin(NAP) reductase
Systematic name: ferredoxin:NAD(P)+ oxidoreductase
Comments: The enzyme from the aerobic bacterium Ralstonia sp. U2 donates electrons to both EC 126.96.36.199, naphthalene 1,2-dioxygenase and EC 188.8.131.52, salicylate 5-hydroxylase . The enzyme from Pseudomonas NCIB 9816 is specific for the ferredoxin associated with naphthalene dioxygenase; it contains FAD and a [2Fe-2S] cluster.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Zhou, N.Y., Al-Dulayymi, J., Baird, M.S. and Williams, P.A. Salicylate 5-hydroxylase from Ralstonia sp. strain U2: a monooxygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase. J. Bacteriol. 184 (2002) 1547-1555. [PMID: 11872705]
2. Haigler, B.E. and Gibson, D.T. Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816. J. Bacteriol. 172 (1990) 457-464. [PMID: 2294092]