IUBMB Enzyme Nomenclature


Accepted name: resorcinol 4-hydroxylase (FADH2)

Reaction: resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O

Glossary: resorcinol = 1,3-dihydroxybenzene
hydroxyquinol = 1,2,4-trihydroxybenzene

Other name(s): graA (gene name)

Systematic name: resorcinol,FADH2:oxygen oxidoreductase (4-hydroxylating)

Comments: The enzyme, characterized from the bacterium Rhizobium sp. strain MTP-10005, uses FADH2 as a substrate rather than a cofactor. FADH2 is provided by a dedicated EC, flavin reductase (NADH). The enzyme participates in the degradation of γ-resorcylate and resorcinol. cf. EC, resorcinol 4-hydroxylase (NADH), and EC, resorcinol 4-hydroxylase (NADPH).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Ohta, Y. and Ribbons, D.W. Bacterial metabolism of resorcinylic compounds: purification and properties of orcinol hydroxylase and resorcinol hydroxylase from Pseudomonas putida ORC. Eur. J. Biochem. 61 (1976) 259-269. [PMID: 1280]

2. Yoshida, M., Oikawa, T., Obata, H., Abe, K., Mihara, H. and Esaki, N. Biochemical and genetic analysis of the γ-resorcylate (2,6-dihydroxybenzoate) catabolic pathway in Rhizobium sp. strain MTP-10005: identification and functional analysis of its gene cluster. J. Bacteriol. 189 (2007) 1573-1581. [PMID: 17158677]

[EC created 2016]

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