IUBMB Enzyme Nomenclature


Accepted name: methanesulfonate monooxygenase (FMNH2)

Reaction: methanesulfonate + FMNH2 + O2 = formaldehyde + FMN + sulfite + H2O

Glossary: methanesulfonate = CH3-SO3-
formaldehyde = H-CHO

Other name(s): msuD (gene name); ssuD (gene name)

Systematic name: methanesulfonate,FMNH2:oxygen oxidoreductase

Comments: The enzyme, characterized from Pseudomonas strains, allows the organisms to utilize methanesulfonate as their sulfur source. It acts in combination with a dedicated NADH-dependent FMN reductase (EC, which provides it with reduced FMN. cf. EC, methanesulfonate monooxygenase (NADH).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kertesz, M.A., Schmidt-Larbig, K. and Wuest, T. A novel reduced flavin mononucleotide-dependent methanesulfonate sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas aeruginosa. J. Bacteriol. 181 (1999) 1464-1473. [PMID: 10049377]

2. Endoh, T., Kasuga, K., Horinouchi, M., Yoshida, T., Habe, H., Nojiri, H. and Omori, T. Characterization and identification of genes essential for dimethyl sulfide utilization in Pseudomonas putida strain DS1. Appl. Microbiol. Biotechnol. 62 (2003) 83-91. [PMID: 12835925]

[EC created 2016]

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