IUBMB Enzyme Nomenclature


Accepted name: all-trans-retinol 3,4-desaturase

Reaction: all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O

For diagram of reaction click here.

Other name(s): CYP27C1 (gene name)

Systematic name: all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase

Comments: A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Enright, J.M., Toomey, M.B., Sato, S.Y., Temple, S.E., Allen, J.R., Fujiwara, R., Kramlinger, V.M., Nagy, L.D., Johnson, K.M., Xiao, Y., How, M.J., Johnson, S.L., Roberts, N.W., Kefalov, V.J., Guengerich, F.P. and Corbo, J.C. Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2. Curr. Biol. 25 (2015) 3048-3057. [PMID: 26549260]

2. Kramlinger, V.M., Nagy, L.D., Fujiwara, R., Johnson, K.M., Phan, T.T., Xiao, Y., Enright, J.M., Toomey, M.B., Corbo, J.C. and Guengerich, F.P. Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. FEBS Lett. 590 (2016) 1304-1312. [PMID: 27059013]

[EC created 2018]

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