IUBMB Enzyme Nomenclature


Accepted name: progesterone monooxygenase

Reaction: progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O

Other name(s): progesterone hydroxylase

Systematic name: progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)

Comments: Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC androst-4-ene-3,17-dione monooxygenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37256-85-2


1. Rahim, M.A. and Sih, C.J. Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain. J. Biol. Chem. 241 (1966) 3615-3623.

[EC created 1972, modified 1999]

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