Reaction: phosphite + AMP + NAD+ = ADP + NADH + H+
Other name(s): apdA (gene name)
Systematic name: phosphite:NAD+ oxidoreductase (ADP-forming)
Comments: The enzyme was characterized from the anaerobic bacteria Desulfotignum phosphitoxidans and Phosphitispora fastidiosa. Activity in vitro required the presence of EC 2.7.4.3, adenylate kinase. cf. EC 1.20.1.1, phosphite dehydrogenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Mao, Z., Fleming, J.R., Mayans, O., Frey, J., Schleheck, D., Schink, B. and Muller, N. AMP-dependent phosphite dehydrogenase, a phosphorylating enzyme in dissimilatory phosphite oxidation. Proc. Natl. Acad. Sci. USA 120 (2023) e2309743120. [PMID: 37922328]