IUBMB Enzyme Nomenclature


Accepted name: all-trans-retinol 13,14-reductase

Reaction: all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor

For diagram of reaction click here.

Other name(s): retinol saturase; RetSat; (13,14)-all-trans-retinol saturase; all-trans-retinol:all-trans-13,14-dihydroretinol saturase

Systematic name: all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase

Comments: The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 418767-56-3


1. Moise, A.R., Kuksa, V., Imanishi, Y. and Palczewski, K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J. Biol. Chem. 279 (2004) 50230-50242. [PMID: 15358783]

[EC created 2005]

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