IUBMB Enzyme Nomenclature


Accepted name: methylenetetrahydrofolate dehydrogenase (NAD+)

Reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+

For diagram of reaction click here.

Other name(s): methylenetetrahydrofolate dehydrogenase (NAD)

Systematic name: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 82062-90-6


1. Moore, M.R., O'Brien, W.E. and Ljungdahl, L.G. Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum. J. Biol. Chem. 249 (1974) 5250-5253. [PMID: 4153026]

[EC created 1978]

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