Reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
For diagram click here.
Other name(s): (R)-canadine synthase
Systematic name: (R)-tetrahydroberberine:NADP+ oxidoreductase
Comments: Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 220.127.116.11 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Bauer, W. and Zenk, M.H. Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro. Tetrahedron Lett. 32 (1991) 487-490.