IUBMB Enzyme Nomenclature


Accepted name: berberine reductase

Reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+

For diagram click here.

Other name(s): (R)-canadine synthase

Systematic name: (R)-tetrahydroberberine:NADP+ oxidoreductase

Comments: Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Bauer, W. and Zenk, M.H. Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro. Tetrahedron Lett. 32 (1991) 487-490.

[EC created 2002]

Return to EC 1.5.1 home page
Return to EC 1.5 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page