IUBMB Enzyme Nomenclature


Accepted name: FAD reductase [NAD(P)H]

Reaction: FADH2 + NAD(P)+ = FAD + NAD(P)H + H+

For diagram of reaction click here.

Other name(s): GTNG_3158 (gene name)

Systematic name: FADH2:NAD(P)+ oxidoreductase

Comments: This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC, FAD reductase (NADH).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Liu, X., Dong, Y., Li, X., Ren, Y., Li, Y., Wang, W., Wang, L. and Feng, L. Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2. Microbiology 156 (2010) 589-595. [PMID: 19942660]

[EC created 2012]

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