IUBMB Enzyme Nomenclature


Accepted name: CoA-disulfide reductase

Reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+

Other name(s): CoA-disulfide reductase (NADH2); NADH2:CoA-disulfide oxidoreductase; CoA:NAD+ oxidoreductase (misleading); CoADR; coenzyme A disulfide reductase

Systematic name: CoA:NADP+ oxidoreductase

Comments: A flavoprotein. Not identical with EC (cystine reductase), EC (glutathione-disulfide reductase) or EC (bis-γ-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].

Links to other databases: BRENDA, EXPASY, KEGG, PDB, Metacyc, CAS registry number: 206770-55-0


1. Setlow, B. and Setlow, P. Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium. J. Bacteriol. 132 (1977) 444-452. [PMID: 410791]

2. delCardayré, S.B., Stock, K.P., Newton, G.L., Fahey, R.C. and Davies, J.E. Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme. J. Biol. Chem. 273 (1998) 5744-5751. [PMID: 9488707]

3. Luba, J., Charrier, V. and Claiborne, A. Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides. Biochemistry 38 (1999) 2725-2737. [PMID: 10052943]

[EC created 1992 as EC, transferred 2002 to EC, modified 2005, modified 2013]

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