IUBMB Enzyme Nomenclature


Accepted name: farnesylcysteine lyase

Reaction: S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2

Other name(s): FC lyase; FCLY

Systematic name: S-(2E,6E)-farnesyl-L-cysteine oxidase

Comments: A flavoprotein (FAD). In contrast to mammalian EC (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Huizinga, D.H., Denton, R., Koehler, K.G., Tomasello, A., Wood, L., Sen, S.E. and Crowell, D.N. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis. Mol Plant 3 (2010) 143-155. [PMID: 19969520]

2. Crowell, D.N., Huizinga, D.H., Deem, A.K., Trobaugh, C., Denton, R. and Sen, S.E. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. Plant J. 50 (2007) 839-847. [PMID: 17425716]

[EC created 2011]

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