IUBMB Enzyme Nomenclature


Accepted name: L-methionine (R)-S-oxide reductase

Reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin

For diagram click here and mechanism click here.

Other name(s): fRMsr; FRMsr; free met-R-(o) reductase; free-methionine (R)-S-oxide reductase

Systematic name: L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]

Comments: Requires NADPH. Unlike EC, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 945954-12-1


1. Etienne, F., Spector, D., Brot, N. and Weissbach, H. A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide. Biochem. Biophys. Res. Commun. 300 (2003) 378-382. [PMID: 12504094]

[EC created 1984 as EC, part transferred 2006 to EC]

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