© IUBMB 2006
Mechanism based on the work of Lowther, W.T., Brot, N., Weissbach, H., Honek, J.F. and Matthews B.W. Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase Proc. Natl. Acad. Sci. USA 97 (2000) 6463-6468 [PMID: 10841552] and Boschi-Muller, S., Azza, S., Sanglier-Cianferani, S., Talfournier, F., Van Dorsselear, A. and Branlant, G. A sulfenic acid enzyme intermediate is involved in the catalytic mechanism of peptide methionine sulfoxide reductase from Escherichia coli. J. Biol. Chem. 275 (2000) 35908-35913 [PMID: 10964927] on EC 1.8.4.11 but presumably applies to EC 1.8.4.12, EC 1.8.4.13 and EC 1.8.4.14.
© IUBMB 2006
After thiol-disulfide exchange, the disulfide bond of the enzyme is reduced by other reductants, often thiols.
enzymes homepage.
EC 1.8.4.11 peptide-L-methionine (S)-S-oxide reductase
EC 1.8.4.12 peptide-methionine (R)-S-oxide reductase
EC 1.8.4.13 L-methionine (S)-S-oxide reductase
EC 1.8.4.14 L-methionine (R)-S-oxide reductase