IUBMB Enzyme Nomenclature


Accepted name: precorrin-2 C20-methyltransferase

Reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A

For diagram click here.

Systematic name: S-adenosyl-L-methionine:precorrin-2 C20-methyltransferase

Comments: This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC, cobalt-factor II C20-methyltransferase, for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 131554-12-6


1. Roessner, C.A., Warren, M.J., Santander, P.J., Atshaves, B.P., Ozaki, S., Stolowich, N.J., Iida, K., Scott, A.I. Expression of Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis. FEBS Lett. 301 (1992) 73-78. [PMID: 1451790]

2. Roessner, C.A., Spencer, J.B., Ozaki, S., Min, C., Atshaves, B.P., Nayar, P., Anousis, N., Stolowich, N.J., Holderman, M.T., Scott, A.I. Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes. Protein Extr. Purif. 6 (1995) 155-163. [PMID: 7606163]

3. Debussche, L., Thibaut, D., Cameron, B., Crouzet, J., Blanche, F.J. Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans. J. Bacteriol. 175 (1993) 7430-7440. [PMID: 8226690]

[EC created 1999]

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