IUBMB Enzyme Nomenclature


Accepted name: cobalt-factor II C20-methyltransferase

Reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III

For diagram click here.

Other name(s): CbiL

Systematic name: S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase

Comments: This enzyme participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway. See EC, precorrin-2 C20-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Spencer, P., Stolowich, N.J., Sumner, L.W. and Scott, A.I. Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium. Biochemistry 37 (1998) 14917-14927. [PMID: 9778368]

[EC created 2004]

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