IUBMB Enzyme Nomenclature


Accepted name: methylene-fatty-acyl-phospholipid synthase

Reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid

Other name(s): unsaturated-phospholipid methyltransferase

Systematic name: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)

Comments: The enzyme transfers a methyl group to the 10-position of a δ-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC cyclopropane-fatty-acyl-phospholipid synthase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37256-90-9


1. Akamatsu, Y. and Law, J.H. Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei. J. Biol. Chem. 245 (1970) 701-708. [PMID: 4313604]

[EC created 1972, modified 1986]

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