IUBMB Enzyme Nomenclature


Accepted name: cyclopropane-fatty-acyl-phospholipid synthase

Reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid

Other name(s): cyclopropane synthetase; unsaturated-phospholipid methyltransferase; cyclopropane synthase; cyclopropane fatty acid synthase; cyclopropane fatty acid synthetase; CFA synthase

Systematic name: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)

Comments: The enzyme adds a methylene group across the 9,10 position of a δ9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC methylene-fatty-acyl-phospholipid synthase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 51845-48-8


1. Chung, A.E. and Law, J.H. Cyclopropane fatty acid synthetase: Partial purification and properties. Biochemistry 3 (1964) 967-974.

2. Zalkin, H., Law, J.H. and Goldfine, H. Enzymatic synthesis of cyclopropane fatty acids catalyzed by bacterial extracts. J. Biol. Chem. 238 (1963) 1242-1248.

[EC created 1986]

Return to EC 2.1.1 home page
Return to EC 2.1 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page