IUBMB Enzyme Nomenclature


Accepted name: guanidinoacetate N-methyltransferase

Reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

For diagram of reaction click here.

Other name(s): GA methylpherase; guanidinoacetate methyltransferase; guanidinoacetate transmethylase; methionine-guanidinoacetic transmethylase; guanidoacetate methyltransferase

Systematic name: S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-75-8


1. Cantoni, G.L. and Scarano, E. The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions. J. Am. Chem. Soc. 76 (1954) 4744 only.

2. Cantoni, G.L. and Vignos, P.J. Enzymatic mechanism of creatine synthesis. J. Biol. Chem. 209 (1954) 647-659.

[EC created 1961]

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