Creatine Biosynthesis

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© IUBMB 2003

Note: The upper part of the diagram shows mammalian metabolism. The three enzymes shown at the bottom, EC, EC, and EC, are not known to occur in mammals.

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arginine biosynthesis.
EC guanidinoacetate N-methyltransferase
EC glycine amidinotransferase
EC creatine kinase
EC N-carbamoylsarcosine amidase
EC N-methylhydantoinase (ATP-hydrolysing)
EC creatinase
EC creatinine deaminase