IUBMB Enzyme Nomenclature


Accepted name: 2,4,6-trihydroxybenzophenone synthase

Reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2

For diagram of reaction click here.

Other name(s): benzophenone synthase (ambiguous); BPS (ambiguous)

Systematic name: malonyl-CoA:benzoyl-CoA malonyltransferase (2,4,6-trihydroxybenzophenone-forming)

Comments: Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC, 2,3',4,6-tetrahydroxybenzophenone synthase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Schmidt, W. and Beerhues, L. Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L. FEBS Lett 420 (1997) 143-146. [PMID: 9459298]

2. Nualkaew, N., Morita, H., Shimokawa, Y., Kinjo, K., Kushiro, T., De-Eknamkul, W., Ebizuka, Y. and Abe, I. Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry 77 (2012) 60-69. [PMID: 22390826]

[EC created 2013]

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