Polyketides are derived from malonyl-CoA often with a starter molecule which is an acyl-CoA or acyl-acp molecule. The reactions shown below all involve chain extension with malonyl-CoA and usually cyclisation reactions.
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aflatoxin biosynthesis
azinomycin B biosynthesis
benzalacetone biosynthesis
β-bitter acid biosynthesis
cannabinoid biosynthesis
coelimycin A1 biosynthesis
1,3-dihydroxy-N-methylacridone biosynthesis
elloramycin biosynthesis
flaviolin biosynthesis
isoliquiritigenin biosynthesis
lovastatin biosynthesis
naringenin chalcone, pinosylvin snd resveratrol biosynthesis
neocarzinostatin biosynthesis
phloroisovalerophenone 2-O-glucoside biosynthesis
tetracycline biosynthesis
EC 2.3.1.151 2,3',4,6-tetrahydroxybenzophenone synthase
EC 2.3.1.156 phloroisovalerophenone synthase
EC 2.3.1.161 lovastatin nonaketide synthase
EC 2.3.1.165 6-methylsalicylic acid synthase
EC 2.3.1.177 3,5-dihydroxybiphenyl synthase
EC 2.3.1.208 4-hydroxycoumarin synthase
EC 2.3.1.216 5,7-dihydroxy-2-methylchromone synthase
EC 2.3.1.220 2,4,6-trihydroxybenzophenone synthase
EC 2.3.1.221 noranthrone synthase
EC 2.3.1.233 1,3,6,8-tetrahydroxynaphthalene synthase
EC 2.3.1.235 tetracenomycin F2 synthase (mechanism)
EC 2.3.1.236 5-methylnaphthoic acid synthase
EC 2.3.1.237 neocarzinostatin naphthoate synthase
EC 2.3.1.253 phloroglucinol synthase
EC 2.3.1.281 coelimycin P1 polyketide synthase