Polyketides Biosynthesis

Polyketides are derived from malonyl-CoA often with a starter molecule which is an acyl-CoA or acyl-acp molecule. The reactions shown below all involve chain extension with malonyl-CoA and usually cyclisation reactions.

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aflatoxin biosynthesis
azinomycin B biosynthesis
benzalacetone biosynthesis
β-bitter acid biosynthesis
cannabinoid biosynthesis
coelimycin A1 biosynthesis
1,3-dihydroxy-N-methylacridone biosynthesis
elloramycin biosynthesis
flaviolin biosynthesis
isoliquiritigenin biosynthesis
lovastatin biosynthesis
naringenin chalcone, pinosylvin snd resveratrol biosynthesis
neocarzinostatin biosynthesis
phloroisovalerophenone 2-O-glucoside biosynthesis
tetracycline biosynthesis
EC 2,3',4,6-tetrahydroxybenzophenone synthase
EC phloroisovalerophenone synthase
EC lovastatin nonaketide synthase
EC 6-methylsalicylic acid synthase
EC 3,5-dihydroxybiphenyl synthase
EC 4-hydroxycoumarin synthase
EC 5,7-dihydroxy-2-methylchromone synthase
EC 2,4,6-trihydroxybenzophenone synthase
EC noranthrone synthase
EC 1,3,6,8-tetrahydroxynaphthalene synthase
EC tetracenomycin F2 synthase (mechanism)
EC 5-methylnaphthoic acid synthase
EC neocarzinostatin naphthoate synthase
EC phloroglucinol synthase
EC coelimycin P1 polyketide synthase