IUBMB Enzyme Nomenclature


Accepted name: 3,5-dihydroxybiphenyl synthase

Reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2

For diagram of reaction click here.

Other name(s): BIS1; biphenyl synthase (ambiguous)

Systematic name: malonyl-CoA:benzoyl-CoA malonyltransferase

Comments: A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC, benzophenone synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 1217551-24-0


1. Liu, B., Beuerle, T., Klundt, T. and Beerhues, L. Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia. Planta 218 (2004) 492-496. [PMID: 14595561]

2. Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. Biphenyl synthase, a novel type III polyketide synthase. Planta 225 (2007) 1495-1503. [PMID: 17109150]

[EC created 2006, modified 2012]

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