Reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2
For diagram of reaction click here.
Other name(s): BIS1; biphenyl synthase (ambiguous)
Systematic name: malonyl-CoA:benzoyl-CoA malonyltransferase
Comments: A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 220.127.116.11, 4-hydroxycoumarin synthase) . This enzyme uses the same starter substrate as EC 18.104.22.168, benzophenone synthase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 1217551-24-0
1. Liu, B., Beuerle, T., Klundt, T. and Beerhues, L. Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia. Planta 218 (2004) 492-496. [PMID: 14595561]
2. Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. Biphenyl synthase, a novel type III polyketide synthase. Planta 225 (2007) 1495-1503. [PMID: 17109150]