IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxycoumarin synthase

Reaction: malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2

For diagram of reaction click here.

Glossary: 2-hydroxybenzoyl-CoA = salicyloyl-CoA

Other name(s): BIS2; BIS3

Systematic name: malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase

Comments: The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC, biphenyl synthase) [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. A novel 4-hydroxycoumarin biosynthetic pathway. Plant Mol. Biol. 72 (2010) 17-25. [PMID: 19757094]

[EC created 2012]

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