Reaction: acetyl-CoA + 17,18-epoxy-17-hydroxycur-19-ene = CoA + diaboline
For diagram of reaction click here
Glossary: 17,18-epoxy-17-hydroxycur-19-ene = (19E)-18-hydroxycur-19-en-17-al = Wieland-Gumlich aldehyde
diaboline = (17R)-acetyl-17,18-epoxy-17-hydroxycur-19-ene
Other name(s): Wieland-Gumlich aldehyde N-acetyltransferase
Systematic name: acetyl-CoA:17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase
Comments: The enzyme has been characterized from a nonstrychnine-producing Strychnos sp. (Strychnos potatorum).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Singh, H., Kapoor, V.K., Phillipson, J.D. and Bisset, N.G. Diaboline from Strychnos potatorum. Phytochemistry 14 (1975) 587-588.
2. Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617-622. [PMID: 35794473]