Biosythesis of Strychnine and Related Alkaloids

Reactions based on Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617-622. [PMID: 35794473]

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geissoschizine biosynthesis
brucine biosynthesis
EC 1.5.1.57 18-hydroxynorfluorocurarine reductase
EC 1.14.14.188 norfluorocurarine 18-hydroxylase
EC 1.14.19.80 geissoschizine oxidase
EC 2.3.1.325 17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase
EC 2.3.1.326 17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase
EC 3.1.1.123 dehydropreakuammicine esterase