Reaction: 17-dehydropreakuammicine + H2O = norfluorocurarine + methanol + CO2
For diagram of reaction click here
Glossary: 17-dehydropreakuammicine = methyl (16S,19E)-17-oxocura-1,19-diene-16-carboxylate
norfluorocurarine = (19E)-cura-2(16),19-dien-17-al
Other name(s): norfluorocurarine synthase; NS1 (gene name); NS2 (gene name)
Systematic name: 17-dehydropreakuammicine hydrolase (decarboxylating)
Comments: The enzyme, characterized from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. The enzyme catalyses the hydrolysis of a methyl ester, which is followed by the spontaneous decarboxylation of the resulting carboxyl group.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617-622. [PMID: 35794473]