EC 2.3.1.81

Reaction: acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N³-acetyl-2-deoxystreptamine antibiotic

For diagram of reaction click here.

Glossary: kanamycin

Other name(s): 3-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase; aminoglycoside N³-acetyltransferase; acetyl-CoA:2-deoxystreptamine-antibiotic N^3'-acetyltransferase (incorrect); aminoglycoside N^3'-acetyltransferase (incorrect)

Systematic name: acetyl-CoA:2-deoxystreptamine-antibiotic N³-acetyltransferase

Comments: Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 60120-42-5

References:

1. Davies, J. and O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob. Agents Chemother. 14 (1978) 69-72. [PMID: 356726]