IUBMB Enzyme Nomenclature


Accepted name: S-methyl-5'-thioinosine phosphorylase

Reaction: S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-α-D-ribose 1-phosphate

Other name(s): MTIP; MTI phosphorylase; methylthioinosine phosphorylase

Systematic name: S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase

Comments: No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Guan, R., Ho, M.C., Almo, S.C. and Schramm, V.L. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry 50 (2011) 1247-1254. [PMID: 21197954]

[EC created 2011]

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