IUBMB Enzyme Nomenclature


Accepted name: thyroid-hormone transaminase

Reaction: L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate

For diagram click here (mechanism).

Other name(s): 3,5-dinitrotyrosine transaminase; thyroid hormone aminotransferase

Systematic name: L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase

Comments: A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 51004-29-6


1. Soffer, R.L., Hechtman, P. and Savage, M. L-Triiodothyronine aminotransferase. J. Biol. Chem. 248 (1973) 1224-1230. [PMID: 4686924]

[EC created 1972]

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