IUBMB Enzyme Nomenclature


Accepted name: tryptophan transaminase

Reaction: L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate

For diagram click here (mechanism).

Other name(s): L-phenylalanine-2-oxoglutarate aminotransferase; tryptophan aminotransferase; 5-hydroxytryptophan-ketoglutaric transaminase; hydroxytryptophan aminotransferase; L-tryptophan aminotransferase; L-tryptophan transaminase

Systematic name: L-tryptophan:2-oxoglutarate aminotransferase

Comments: A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9022-98-4


1. George, H. and Gabay, S. Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase. Biochim. Biophys. Acta 167 (1968) 555-566. [PMID: 5722279]

2. O'Neil, S.R. and DeMoss, R.D. Tryptophan transaminase from Clostridium sporogenes. Arch. Biochem. Biophys. 127 (1968) 361-368. [PMID: 5697992]

3. Tangen, O., Fonnum, F. and Haavaldsen, R. Separation and purification of aromatic amino acid transaminases from rat brain. Biochim. Biophys. Acta 96 (1965) 82-90.

[EC created 1972]

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