Reaction: L-alanine + glyoxylate = pyruvate + glycine
For diagram click here (mechanism).
Other name(s): AGT; alanine-glyoxylate aminotransferase; alanine-glyoxylic aminotransferase; L-alanine-glycine transaminase
Systematic name: L-alanine:glyoxylate aminotransferase
Comments: A pyridoxal-phosphate protein. With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyses the reaction of EC 2.6.1.51 serine—pyruvate transaminase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9015-67-2
References:
1. Noguchi, T., Okuno, E., Takada, Y., Minatogawa, Y., Okai, K. and Kido, R. Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species. Biochem. J. 169 (1978) 113-122. [PMID: 629740]
2. Okuno, E., Minatogawa, Y. and Kido, R. Co-purification of alanine-glyoxylate aminotransferase with 2-aminobutyrate aminotransferase in rat kidney. Biochim. Biophys. Acta 715 (1982) 97-104. [PMID: 6803844]
3. Thompson, J.S. and Richardson, K.E. Isolation and characterization of an L-alanine: glyoxylate aminotransferase from human liver. J. Biol. Chem. 242 (1967) 3614-3619. [PMID: 6038488]