IUBMB Enzyme Nomenclature


Accepted name: alanine—glyoxylate transaminase

Reaction: L-alanine + glyoxylate = pyruvate + glycine

For diagram click here (mechanism).

Other name(s): AGT; alanine-glyoxylate aminotransferase; alanine-glyoxylic aminotransferase; L-alanine-glycine transaminase

Systematic name: L-alanine:glyoxylate aminotransferase

Comments: A pyridoxal-phosphate protein. With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyses the reaction of EC serine—pyruvate transaminase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9015-67-2


1. Noguchi, T., Okuno, E., Takada, Y., Minatogawa, Y., Okai, K. and Kido, R. Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species. Biochem. J. 169 (1978) 113-122. [PMID: 629740]

2. Okuno, E., Minatogawa, Y. and Kido, R. Co-purification of alanine-glyoxylate aminotransferase with 2-aminobutyrate aminotransferase in rat kidney. Biochim. Biophys. Acta 715 (1982) 97-104. [PMID: 6803844]

3. Thompson, J.S. and Richardson, K.E. Isolation and characterization of an L-alanine: glyoxylate aminotransferase from human liver. J. Biol. Chem. 242 (1967) 3614-3619. [PMID: 6038488]

[EC created 1972, modified 1982]

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