IUBMB Enzyme Nomenclature


Accepted name: serine—pyruvate transaminase

Reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

For diagram click here (mechanism).

Other name(s): SPT; hydroxypyruvate:L-alanine transaminase

Systematic name: L-serine:pyruvate aminotransferase

Comments: A pyridoxal-phosphate protein. The liver enzyme may be identical with EC alanine—glyoxylate transaminase.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9030-88-0


1. Cheung, G.P., Rosenblum, I. and Sallach, H.J. Comparative studies of enzymes related to serine metabolism in higher plants. Plant Physiol. 43 (1968) 1813-1820. [PMID: 5699148]

2. Kretovich, V.L. and Stepanovich, K.M. [The synthesis of serine from hydroxypyruvate in plants.] Dokl. Akad. Nauk S.S.S.R. 139 (1961) 488-490. (in Russian)

3. Sallach, H.J. Formation of serine from hydroxypyruvate and L-alanine. J. Biol. Chem. 223 (1956) 1101-1108.

[EC created 1972]

Return to EC 2.6.1 home page
Return to EC 2.6 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page